The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) definition of clinical remission in gout.

IF 20.3 1区医学 Q1 RHEUMATOLOGY

Annals of the Rheumatic Diseases Pub Date : 2025-06-18 DOI:10.1016/j.ard.2025.05.017

Adwoa Dansoa Tabi-Amponsah, Sarah Stewart, Lisa K Stamp, William J Taylor, Robert Terkeltaub, Nicola Dalbeth

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引用次数: 0

Abstract

Objectives: In 2016, rheumatologists and gout researchers developed a preliminary definition for gout remission. A subsequent qualitative study involving people with gout identified redundancies in the preliminary definition, prompting the development of a simplified definition consisting of no gout flares over 12 months, absence of subcutaneous tophi and serum urate <0.36 mmol/L (6 mg/dL) over 12 months. Here, we describe the evaluation and validation of the simplified definition and endorsement of this definition as the Gout, Hyperuricemia, and Crystal-Associated Disease Network (G-CAN) definition of clinical remission in gout.

Methods: After establishment of the simplified definition, this multiphase project involved consecutive steps: analysis of the definition across a range of gout clinical trial datasets and study populations, summary of evaluation and validation of this definition presented to G-CAN members, discussion of this definition by G-CAN members, voting and G-CAN Board endorsement.

Results: The simplified definition exhibited face validity, construct validity, predictive validity, feasibility, responsiveness, and discrimination across a range of gout clinical trial datasets. It also captured both inflammatory disease activity and urate burden in gout and reflected the patient perspective on gout remission. It was suggested by G-CAN members to consider the definition as one for 'clinical gout remission' since there is no domain evaluating complete crystal dissolution. In voting, this definition was supported by 98% of G-CAN members, and the G-CAN Board endorsed the definition.

Conclusions: The G-CAN definition is feasible and has high validity. We recommend that this definition is used when assessing clinical remission in gout.

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痛风，高尿酸血症和晶体相关疾病网络（G-CAN）痛风临床缓解的定义。

目的：2016年，风湿病学家和痛风研究人员制定了痛风缓解的初步定义。随后一项涉及痛风患者的定性研究发现了初步定义中的冗余，促使简化定义的发展，包括12个月内无痛风发作，缺乏皮下痛风石和血清尿酸。方法：在简化定义建立后，这个多阶段项目包括连续的步骤：在一系列痛风临床试验数据集和研究人群中分析该定义，向G-CAN成员提交该定义的评估和验证总结，G-CAN成员对该定义的讨论，投票和G-CAN董事会认可。结果：简化定义在一系列痛风临床试验数据集中表现出面孔效度、结构效度、预测效度、可行性、响应性和区别性。它还捕获了痛风中的炎症性疾病活动性和尿酸负荷，并反映了患者对痛风缓解的看法。G-CAN成员建议考虑将其定义为“临床痛风缓解”，因为没有评估晶体完全溶解的领域。在投票中，该定义得到了98%的G-CAN成员的支持，G-CAN董事会批准了该定义。结论：G-CAN定义是可行的，具有较高的效度。我们建议在评估痛风的临床缓解时使用这个定义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of the Rheumatic Diseases 医学-风湿病学

CiteScore

35.00

自引率

9.90%

发文量

3728

审稿时长

1.4 months

期刊介绍： Annals of the Rheumatic Diseases (ARD) is an international peer-reviewed journal covering all aspects of rheumatology, which includes the full spectrum of musculoskeletal conditions, arthritic disease, and connective tissue disorders. ARD publishes basic, clinical, and translational scientific research, including the most important recommendations for the management of various conditions.