The association of peripheral blood METTL3 mRNA expression levels with prediabetes and type 2 diabetes mellitus: the Henan rural cohort study.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2025-06-20 DOI:10.1007/s00592-025-02542-y

Yujie Jiang, Xiaoying Ren, Yuqian Li, Gaohua Chang, Xintao Pan, Yahui Zhang, Chongjian Wang, Xiaotian Liu

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引用次数: 0

Abstract

Aim: We aimed to investigate the association of peripheral blood METTL3 (Methyltransferase Like 3) mRNA expression levels with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM).

Materials and methods: A case-control study including 1501 participants from the Henan Rural Cohort study was performed. Peripheral blood METTL3 mRNA expression levels were quantified by qRT-PCR. Binary logistic regression was used to generate odds ratio (OR) and 95% confidence intervals (CI) for the risk of IFG and T2DM. Restricted cubic spline was used to generate the dose-response relationship between METTL3 mRNA expression levels and IFG and T2DM.

Results: METTL3 mRNA expression levels were downregulated in T2DM compared with normal glucose tolerance (NGT) (4.03 ± 1.09 vs. 3.96 ± 0.93). After adjusting covariates, the risk of developing IFG in METTL3 mRNA high expression levels group was 30% higher than that in the low expression levels group (OR = 1.30,95%CI:1.02,1.65). Conversely, METTL3 mRNA expression levels were negatively correlated with T2DM(OR = 0.83,95%CI:0.72,0.96) compared to the NGT group. METTL3 mRNA expression levels showed a non-linear correlation with both IFG and T2DM.

Conclusion: METTL3 mRNA expression levels exhibited opposing effects on IFG and T2DM. Elevated METTL3 mRNA levels were positively associated with IFG risk but inversely associated with T2DM risk.

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外周血METTL3 mRNA表达水平与前驱糖尿病和2型糖尿病的关系：河南农村队列研究

目的：研究外周血METTL3（甲基转移酶样3）mRNA表达水平与空腹血糖（IFG）和2型糖尿病（T2DM）的关系。材料与方法：选取河南省农村队列研究的1501名受试者进行病例对照研究。采用qRT-PCR检测外周血METTL3 mRNA表达水平。使用二元逻辑回归生成IFG和T2DM风险的比值比（OR）和95%置信区间（CI）。采用限制性三次样条法建立METTL3 mRNA表达水平与IFG和T2DM之间的剂量-反应关系。结果：与正常糖耐量（NGT）相比，T2DM患者METTL3 mRNA表达水平下调（4.03±1.09比3.96±0.93）。调整协变量后，METTL3 mRNA高表达组发生IFG的风险比低表达组高30% （OR = 1.30,95%CI:1.02,1.65）。相反，与NGT组相比，METTL3 mRNA表达水平与T2DM呈负相关（OR = 0.83,95%CI:0.72,0.96）。METTL3 mRNA表达水平与IFG和T2DM均呈非线性相关。结论：METTL3 mRNA表达水平对IFG和T2DM的影响相反。METTL3 mRNA水平升高与IFG风险呈正相关，但与T2DM风险呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.