The association of race and ethnicity with risk-reducing mastectomies in patients with non-BRCA mutations

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2025-06-18 DOI:10.1016/j.amjsurg.2025.116485

Koumani W. Ntowe , Samantha M. Thomas , Juliet C. Dalton , Ebunoluwa Olunuga , Ton Wang , Akiko Chiba , Jennifer K. Plichta

{"title":"The association of race and ethnicity with risk-reducing mastectomies in patients with non-BRCA mutations","authors":"Koumani W. Ntowe , Samantha M. Thomas , Juliet C. Dalton , Ebunoluwa Olunuga , Ton Wang , Akiko Chiba , Jennifer K. Plichta","doi":"10.1016/j.amjsurg.2025.116485","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>We compared rates of risk reducing mastectomies (RRM) in patients with breast cancer (BC)-related pathogenic variants.</div></div><div><h3>Methods</h3><div>Female patients ages ≥18 with a BC-related pathogenic variant, without a concurrent or prior BC diagnosis, were identified from a single academic center's database. Patients were stratified by BRCA mutations, high penetrance mutations (HPM), and moderate penetrance mutations (MPM). Race and ethnicity were classified as non-Hispanic White (NHW), non-Hispanic Black (NHB), non-Hispanic other (NHO), and Hispanic.</div></div><div><h3>Results</h3><div>Our study included 528 patients, which included 79.2 % (n = 418) NHW, 7.0 % (n = 37) NHB, 3.6 % (n = 19) NHO, and 3.4 % (n = 18) Hispanic patients. Overall, 16.5 % of patients underwent RRM: 18.4 % of NHW, 10.8 % of NHB, 5.6 % of Hispanic (p = 0.45). For NHB and Hispanic patients, no individuals with HPMs (NHB 0/6, Hispanic 0/5) or MPMs (NHB 0/11, Hispanic 0/4) underwent RRM.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that race and ethnicity may be associated with the decision to undergo RRM.</div></div>","PeriodicalId":7771,"journal":{"name":"American journal of surgery","volume":"247 ","pages":"Article 116485"},"PeriodicalIF":2.7000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002961025003083","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

We compared rates of risk reducing mastectomies (RRM) in patients with breast cancer (BC)-related pathogenic variants.

Methods

Female patients ages ≥18 with a BC-related pathogenic variant, without a concurrent or prior BC diagnosis, were identified from a single academic center's database. Patients were stratified by BRCA mutations, high penetrance mutations (HPM), and moderate penetrance mutations (MPM). Race and ethnicity were classified as non-Hispanic White (NHW), non-Hispanic Black (NHB), non-Hispanic other (NHO), and Hispanic.

Results

Our study included 528 patients, which included 79.2 % (n = 418) NHW, 7.0 % (n = 37) NHB, 3.6 % (n = 19) NHO, and 3.4 % (n = 18) Hispanic patients. Overall, 16.5 % of patients underwent RRM: 18.4 % of NHW, 10.8 % of NHB, 5.6 % of Hispanic (p = 0.45). For NHB and Hispanic patients, no individuals with HPMs (NHB 0/6, Hispanic 0/5) or MPMs (NHB 0/11, Hispanic 0/4) underwent RRM.

Conclusions

Our findings suggest that race and ethnicity may be associated with the decision to undergo RRM.

查看原文本刊更多论文

非brca突变患者的种族和民族与降低风险的乳房切除术的关系

我们比较了乳腺癌（BC）相关致病变异患者的降低风险乳房切除术（RRM）的发生率。方法从单一学术中心的数据库中筛选年龄≥18岁的BC相关致病变异的女性患者，无并发或既往BC诊断。根据BRCA突变、高外显率突变（HPM）和中等外显率突变（MPM）对患者进行分层。种族和民族分为非西班牙裔白人（NHW）、非西班牙裔黑人（NHB）、非西班牙裔其他（NHO）和西班牙裔。结果纳入528例患者，其中NHW占79.2% (n = 418)， NHB占7.0% (n = 37)， NHO占3.6% (n = 19)， Hispanic占3.4% （n = 18）。总体而言，16.5%的患者接受了RRM: 18.4%的NHW患者，10.8%的NHB患者，5.6%的Hispanic患者（p = 0.45）。对于NHB和Hispanic患者，没有hpm （NHB 0/6, Hispanic 0/5）或mpm （NHB 0/11, Hispanic 0/4）患者进行RRM。结论我们的研究结果表明，种族和民族可能与接受RRM的决定有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.