Protective impact of physical exercise on methamphetamine-induced neuroinflammation and neurogenesis impairment depends on the activity level

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-06-17 DOI:10.1016/j.bbi.2025.06.025

Mateusz Smolarz , Magdalena Dębiec , Gracjana Zając , Natalia Pondel , Katarzyna Bogus , Agnieszka Kosowska , Ewelina Pieprzyca , Bogusława Orzechowska-Wylęgała , Andrzej Małecki , Marta Nowacka-Chmielewska , Michal Toborek

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引用次数: 0

Abstract

One of the outcomes of methamphetamine (METH) misuse is impaired hippocampal function. In addition, regular physical exercise has been proposed as an effective behavioral intervention with numerous health benefits, particularly in the treatment of drug misuse. In this study, we evaluated the impact of physical exercise on METH-induced neurotoxicity and inflammation in male and female adult mice. Importantly, we assessed whether the protective effects of exercise vary depending on activity levels. Our findings indicate that METH causes neuroinflammation, abnormal neurogenesis, and cognitive impairment in mice, with notable sexual dimorphism in response to METH toxicity. In addition, the protective effect of physical exercise against METH-induced neuroinflammation and neurogenesis impairment depended on the activity level. Overall, our results indicate the importance of introducing tailored physical exercise protocols into treatment and recovery strategies for individuals who misuse psychoactive substances, such as METH.

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体育锻炼对甲基苯丙胺诱导的神经炎症和神经发生损伤的保护作用取决于活动水平

滥用甲基苯丙胺（冰毒）的后果之一是海马功能受损。此外，有规律的体育锻炼被认为是一种有效的行为干预，具有许多健康益处，特别是在治疗药物滥用方面。在这项研究中，我们评估了体育锻炼对雄性和雌性成年小鼠甲基苯丙胺诱导的神经毒性和炎症的影响。重要的是，我们评估了运动的保护作用是否因活动水平而异。我们的研究结果表明，甲基苯丙胺引起小鼠神经炎症、神经发生异常和认知障碍，并在甲基苯丙胺毒性反应中表现出明显的性别二态性。此外，体育锻炼对甲基苯丙胺诱导的神经炎症和神经发生损伤的保护作用取决于活动水平。总的来说，我们的研究结果表明，在滥用精神活性物质（如冰毒）的个体的治疗和康复策略中引入量身定制的体育锻炼方案的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.