Thrombin generation assay in venous thromboembolism: A scoping review

IF 3.7 3区医学 Q1 HEMATOLOGY

Thrombosis research Pub Date : 2025-06-15 DOI:10.1016/j.thromres.2025.109384

Maria Eduarda Machado Souza , Letícia Gonçalves Resende Ferreira , Nádia Regina Oliveira Silva , Livian Rabelo Lopes , Maria das Graças Carvalho , Danyelle Romana Alves Rios

{"title":"Thrombin generation assay in venous thromboembolism: A scoping review","authors":"Maria Eduarda Machado Souza , Letícia Gonçalves Resende Ferreira , Nádia Regina Oliveira Silva , Livian Rabelo Lopes , Maria das Graças Carvalho , Danyelle Romana Alves Rios","doi":"10.1016/j.thromres.2025.109384","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To describe the relationship, through a scoping review, between thrombin generation assay (TGA) parameters and venous thromboembolism (VTE).</div></div><div><h3>Material and methods</h3><div>A systematic search was carried out in the PubMed/MEDLINE, Embase, Cochrane, Virtual Health Library, Web of Science, and Scopus databases using descriptors for VTE and thrombin generation. Human studies assessing the association between TGA parameters and the occurrence of VTE were included. Screening of the title/abstract and full text was carried out independently by two researchers and divergent classifications were resolved by a third examiner.</div></div><div><h3>Results</h3><div>5204 studies were found, of which 90 were included after screening and full reading. The articles were grouped according to the study population and the factors associated with VTE: unprovoked VTE [33], cancer [20], hereditary/acquired thrombophilias [12], trauma/hospitalization [11], use of hormone replacement therapy/combined oral contraceptives [6], pregnancy [4] and use of anticoagulants [4]. The studies included were predominantly conducted in European countries between 2001 and 2024. Most of the studies were prospective cohort studies and used the Calibrated Automated Thrombogram (CAT) method to perform the TGA. The TGA parameters evaluated were mainly ETP and peak, which were elevated in patients with VTE in all the subgroups assessed. The TGA was able to predict the risk of primary and recurrent VTE and proved to be a useful tool for managing therapeutic regimens with anticoagulants in patients who suffered VTE.</div></div><div><h3>Conclusion</h3><div>The included studies demonstrated that TGA is a promising test in the context of VTE.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"252 ","pages":"Article 109384"},"PeriodicalIF":3.7000,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Thrombosis research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0049384825001343","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To describe the relationship, through a scoping review, between thrombin generation assay (TGA) parameters and venous thromboembolism (VTE).

Material and methods

A systematic search was carried out in the PubMed/MEDLINE, Embase, Cochrane, Virtual Health Library, Web of Science, and Scopus databases using descriptors for VTE and thrombin generation. Human studies assessing the association between TGA parameters and the occurrence of VTE were included. Screening of the title/abstract and full text was carried out independently by two researchers and divergent classifications were resolved by a third examiner.

Results

5204 studies were found, of which 90 were included after screening and full reading. The articles were grouped according to the study population and the factors associated with VTE: unprovoked VTE [33], cancer [20], hereditary/acquired thrombophilias [12], trauma/hospitalization [11], use of hormone replacement therapy/combined oral contraceptives [6], pregnancy [4] and use of anticoagulants [4]. The studies included were predominantly conducted in European countries between 2001 and 2024. Most of the studies were prospective cohort studies and used the Calibrated Automated Thrombogram (CAT) method to perform the TGA. The TGA parameters evaluated were mainly ETP and peak, which were elevated in patients with VTE in all the subgroups assessed. The TGA was able to predict the risk of primary and recurrent VTE and proved to be a useful tool for managing therapeutic regimens with anticoagulants in patients who suffered VTE.

Conclusion

The included studies demonstrated that TGA is a promising test in the context of VTE.

查看原文本刊更多论文

静脉血栓栓塞中的凝血酶生成测定：范围综述

目的通过综述，探讨凝血酶生成测定（TGA）参数与静脉血栓栓塞（VTE）之间的关系。材料和方法系统检索PubMed/MEDLINE、Embase、Cochrane、Virtual Health Library、Web of Science和Scopus数据库，使用VTE和凝血酶生成的描述符。包括评估TGA参数与静脉血栓栓塞发生之间关系的人体研究。标题/摘要和全文的筛选由两名研究人员独立进行，不同的分类由第三名审查员解决。结果共纳入研究5204篇，经筛选和全读后纳入90篇。文章根据研究人群和与静脉血栓栓塞相关的因素进行分组：非诱发性静脉血栓栓塞[33]、癌症[33]、遗传性/获得性血栓形成[12]、创伤/住院[11]、使用激素替代疗法/联合口服避孕药[6]、妊娠[4]和使用抗凝血剂[4]。这些研究主要是在2001年至2024年间在欧洲国家进行的。大多数研究是前瞻性队列研究，并使用校准自动血栓图（CAT）方法进行TGA。评估的TGA参数主要为ETP和peak，在所有评估的亚组中，VTE患者的ETP和peak均升高。TGA能够预测原发性和复发性静脉血栓栓塞的风险，并被证明是管理静脉血栓栓塞患者抗凝治疗方案的有用工具。结论纳入的研究表明TGA是一种很有前途的VTE检测方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Thrombosis research 医学-外周血管病

CiteScore

14.60

自引率

4.00%

发文量

364

审稿时长

31 days

期刊介绍： Thrombosis Research is an international journal dedicated to the swift dissemination of new information on thrombosis, hemostasis, and vascular biology, aimed at advancing both science and clinical care. The journal publishes peer-reviewed original research, reviews, editorials, opinions, and critiques, covering both basic and clinical studies. Priority is given to research that promises novel approaches in the diagnosis, therapy, prognosis, and prevention of thrombotic and hemorrhagic diseases.