Efficacy of Sodium Valproate in Behavioral and Psychological Symptoms of Dementia: A Retrospective Observational Study from PUMCH Dementia Cohort.

Yuyue Qiu, Li Shang, Tianyi Wang, Yuhan Jiang, Jialu Bao, Wenjun Wang, Bo Li, Yixuan Huang, Liling Dong, Chenhui Mao, Jing Gao
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Abstract

Introduction: Behavioral and Psychological Symptoms of Dementia (BPSD) pose significant challenges for individuals with dementia and their caregivers. Agitation symptoms, in particular, present a complex management dilemma as there is a lack of consensus regarding pharmacotherapy, specifically with respect to the controversial use of valproate formulations. This study aims to assess the effectiveness of valproate treatment in addressing BPSD, with a specific focus on managing agitation symptoms in individuals with dementia.

Methods: A retrospective analysis was conducted at Peking Union Medical College Hospital (PUMCH) on patients diagnosed with BPSD who received valproate formulations between 2013 and 2023. Patients were classified into 'effective,' 'ineffective,' and 'unknown' groups based on their response to valproate treatment, and the distribution of BPSD symptoms between the effective and ineffective groups was compared.

Results: Among the 116 patients studied, 62.1% exhibited effective responses, 12.1% showed ineffectiveness, and 25.9% had uncertain outcomes with valproate therapy. While the effective group displayed a higher prevalence of agitation symptoms and other behaviors like wandering, restricted and repetitive behaviors, and sleep disturbances compared to the ineffective group, these differences did not reach statistical significance (p = 0.156, 1.000, 0.899, 0.283). Patients in the ineffective group were more likely to experience aggression with comorbid psychotic symptoms compared to those in the effective group (p = 0.023).

Conclusion: The findings suggest that tailored valproate treatment at low doses may be beneficial in managing agitation without psychosis in Asian BPSD patients. Further validation through randomized controlled trials is essential to substantiate these observations.

丙戊酸钠对痴呆行为和心理症状的疗效:来自PUMCH痴呆队列的回顾性观察研究
导读:痴呆症的行为和心理症状(BPSD)对痴呆症患者及其护理人员构成了重大挑战。特别是躁动症状,呈现出一个复杂的管理困境,因为在药物治疗方面缺乏共识,特别是在有争议的丙戊酸制剂的使用方面。本研究旨在评估丙戊酸治疗BPSD的有效性,特别关注痴呆患者的躁动症状管理。方法:回顾性分析北京协和医院2013 - 2023年使用丙戊酸酯制剂治疗的BPSD患者。根据患者对丙戊酸治疗的反应将患者分为“有效”、“无效”和“未知”组,并比较有效组和无效组之间BPSD症状的分布。结果:在所研究的116例患者中,62.1%表现出有效反应,12.1%表现为无效,25.9%的丙戊酸盐治疗结果不确定。与无效组相比,有效组在躁动症状及徘徊、限制性重复行为、睡眠障碍等行为的发生率较高,但差异无统计学意义(p = 0.156、1.000、0.899、0.283)。与有效组相比,无效组患者更有可能经历攻击并伴有精神症状(p = 0.023)。结论:研究结果表明,低剂量的丙戊酸治疗可能有利于控制亚洲BPSD患者无精神病的躁动。通过随机对照试验进一步验证这些观察结果是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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