Tremor and Ataxia in Paraneoplastic Anti-Diacylglycerol Lipase Alpha (DAGLA) Cerebellitis.

IF 2.7 3区医学 Q3 NEUROSCIENCES

Cerebellum Pub Date : 2025-06-18 DOI:10.1007/s12311-025-01875-2

José Fidel Baizabal-Carvallo, Raquel Ruiz-García, Laura Naranjo, Francesc Graus

引用次数: 0

Abstract

Antibodies directed against the enzyme diacylglycerol lipase alpha (DAGLA) have been recently discovered to cause a severe autoimmune cerebellar syndrome. We report a patient with DAGLA antibodies with prominent tremor and ataxia occurring in the context of a malignant melanoma, indicating that these antibodies may also occur in paraneoplastic cerebellar degeneration.

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副肿瘤抗二酰基甘油脂肪酶α (DAGLA)小脑炎的震颤和共济失调。

最近发现针对二酰基甘油脂肪酶α (DAGLA)的抗体可引起严重的自身免疫性小脑综合征。我们报告了一个患者与DAGLA抗体显著震颤和共济失调发生在恶性黑色素瘤的背景下，表明这些抗体也可能发生在副肿瘤小脑变性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebellum 医学-神经科学

CiteScore

6.40

自引率

14.30%

发文量

150

审稿时长

4-8 weeks

期刊介绍： Official publication of the Society for Research on the Cerebellum devoted to genetics of cerebellar ataxias, role of cerebellum in motor control and cognitive function, and amid an ageing population, diseases associated with cerebellar dysfunction. The Cerebellum is a central source for the latest developments in fundamental neurosciences including molecular and cellular biology; behavioural neurosciences and neurochemistry; genetics; fundamental and clinical neurophysiology; neurology and neuropathology; cognition and neuroimaging. The Cerebellum benefits neuroscientists in molecular and cellular biology; neurophysiologists; researchers in neurotransmission; neurologists; radiologists; paediatricians; neuropsychologists; students of neurology and psychiatry and others.