David H Margarit, Marcela V Reale, Gustavo Paccosi, Lilia M Romanelli
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引用次数: 0
Abstract
This study explores the systemic interactions between cancer stem cell markers (CSCMs) and cancer-affected organs through a hypergraph-based approach. By modeling organs as nodes and CSCMs as hyperedges, we capture multiway relationships beyond conventional pairwise analyses. Using the Louvain algorithm, we identify clusters of organs with shared CSCM profiles, revealing potential tumorigenic pathways and functional networks. Additionally, O-information quantifies redundancy and synergy, highlighting CSCMs with systemic influence on tumor progression and metastasis. These findings provide a structured framework for understanding CSCM dynamics across organ systems, offering insights that may inform targeted, multiorgan therapeutic strategies.
期刊介绍：
Physical Review E (PRE), broad and interdisciplinary in scope, focuses on collective phenomena of many-body systems, with statistical physics and nonlinear dynamics as the central themes of the journal. Physical Review E publishes recent developments in biological and soft matter physics including granular materials, colloids, complex fluids, liquid crystals, and polymers. The journal covers fluid dynamics and plasma physics and includes sections on computational and interdisciplinary physics, for example, complex networks.
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