ASSESSING THE PREDICTIVE VALUE OF THE C-REACTIVE PROTEIN AND NEUTROPHIL-TO-LYMPHOCYTE RATIO COMBINED SCORE FOR ORGAN FAILURE IN ACUTE PANCREATITIS.

Q2 Medicine

Arquivos de Gastroenterologia Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI:10.1590/S0004-2803.24612024-119

Jean Félix Piñerúa-Gonsálvez, María Lourdes Ruiz-Rebollo, Luis Fernández-Salazar

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引用次数: 0

Abstract

Background: Acute pancreatitis (AP) is a common gastrointestinal disorder, with organ failure being the primary cause of mortality. This study evaluates the combined score of C-reactive protein level and neutrophil-to-lymphocyte ratio (C-NLR score), as a predictor of organ failure.

Methods: A retrospective analysis was conducted on AP patients admitted to the Hospital Clínico Universitario de Valladolid between March 2014 and January 2022. The C-NLR score was calculated from admission data: patients with both elevated neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) were assigned a score of 2, those with one elevated marker received a score of 1, and a score of 0 was given to those with neither.

Results: A total of 778 patients were included: 611 with mild AP (MAP), 123 with moderately severe AP (MSAP), and 44 with severe AP (SAP). A C-NLR score of 2 was most frequently observed in patients with MSAP (56.1%) and SAP (56.85%), while a score of 1 was more common in patients with MAP (46.9%). Multivariable logistic regression analysis revealed that a C-NLR score of 2 significantly increased the likelihood of organ failure by threefold (OR 3.176; 95% CI 1.297-7.775).

Conclusion: The C-NLR score could be a useful supplementary tool for predicting organ failure in AP, complementing traditional scoring systems.

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评估c反应蛋白和中性粒细胞与淋巴细胞比值联合评分对急性胰腺炎器官衰竭的预测价值。

背景：急性胰腺炎（AP）是一种常见的胃肠道疾病，器官衰竭是死亡的主要原因。本研究评估了c反应蛋白水平和中性粒细胞与淋巴细胞比值（C-NLR评分）的综合评分，作为器官衰竭的预测指标。方法：回顾性分析2014年3月至2022年1月期间在Clínico巴利亚多利德大学医院住院的AP患者。根据入院资料计算C-NLR评分：中性粒细胞与淋巴细胞比值（NLR）和c反应蛋白（CRP）均升高的患者评分为2分，其中一项指标升高的患者评分为1分，两项指标均升高的患者评分为0分。结果：共纳入778例患者：轻度AP (MAP) 611例，中重度AP (MSAP) 123例，重度AP (SAP) 44例。C-NLR评分为2分在MSAP（56.1%）和SAP（56.85%）患者中最为常见，而1分在MAP患者中更为常见（46.9%）。多变量logistic回归分析显示，C-NLR评分为2分时，发生器官衰竭的可能性显著增加3倍(OR 3.176；95% ci 1.297-7.775)。结论：C-NLR评分可作为预测AP脏器功能衰竭的辅助工具，补充传统评分系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de Gastroenterologia Medicine-Gastroenterology

CiteScore

2.00

自引率

0.00%

发文量

109

审稿时长

9 weeks

期刊介绍： The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.