The Application of Opacification-Development Ratio Based on CT Scan for Diagnosing Pediatric Chronic Rhinosinusitis.

IF 2.8 3区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Therapeutics and Clinical Risk Management Pub Date : 2025-06-13 eCollection Date: 2025-01-01 DOI:10.2147/TCRM.S520879

Jun Zhang, Anni Yang, Tengyu Chen, Yufeng Cao, Qiliang Lv, Yingxiang Xu, Zhenpeng Liao, Xianzhen Chen, Zhongkang Ye, Renjie Lai, Haiyu Hong

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引用次数: 0

Abstract

Purpose: To investigate the diagnostic potency of the opacification-development ratio (ODR) for pediatric chronic rhinosinusitis based on CT scanning.

Patients and methods: Children aged 0-15 years who underwent nasal CT scanning from August 2011 through July 2021 were included in the research. The area under receiver operating characteristic curve (AUC) and predictive value were used to assess the diagnostic accuracy of the ODR and Lund-Mackay score based on CT scanning.

Results: A total of 1820 patients (217 in the positive symptom group and 1603 in the negative symptom group) who underwent CT scanning were included in the study. A significant positive correlation was observed between the ODR and the Lund-Mackay score in all age groups. In children aged 0-15 years, the AUC of the ODR and the Lund-Mackay score were 0.7970 and 0.7719, respectively (p > 0.05). The optimal cut-off value for the ODR was 25.83, with a sensitivity of 57.14% and a specificity of 94.2%. In contrast, the optimal cut-off value for the Lund-Mackay score was 6.5, with a sensitivity of 6.5% and a specificity of 85.84%. Notably, the ODR score demonstrated significantly superior performance compared to the Lund-Mackay score in children aged 0-4 years (p < 0.001).

Conclusion: In diagnosing pediatric chronic rhinosinusitis, the use of CT scans is associated with a higher rate of false positives when compared to clinical symptoms. The ODR score based on CT scanning is a valuable diagnostic tool for chronic rhinosinusitis in children aged 0-11, particularly those aged 0-4.

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CT扫描混浊显影比在小儿慢性鼻窦炎诊断中的应用。

目的：探讨CT扫描对儿童慢性鼻窦炎的诊断价值。患者和方法：研究纳入了2011年8月至2021年7月期间接受鼻腔CT扫描的0-15岁儿童。采用受者工作特征曲线下面积（AUC）和预测值评估CT扫描ODR和Lund-Mackay评分的诊断准确性。结果：共纳入1820例CT扫描患者（阳性症状组217例，阴性症状组1603例）。各年龄组ODR与Lund-Mackay评分呈显著正相关。0 ~ 15岁儿童的ODR和Lund-Mackay评分的AUC分别为0.7970和0.7719 （p < 0.05）。ODR最佳临界值为25.83，敏感性为57.14%，特异性为94.2%。相比之下，Lund-Mackay评分的最佳临界值为6.5，敏感性为6.5%，特异性为85.84%。值得注意的是，与Lund-Mackay评分相比，0-4岁儿童的ODR评分表现出显著优于Lund-Mackay评分（p < 0.001）。结论：在诊断儿童慢性鼻窦炎时，与临床症状相比，使用CT扫描与更高的假阳性率相关。基于CT扫描的ODR评分是0-11岁儿童特别是0-4岁儿童慢性鼻窦炎的有价值的诊断工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-

CiteScore

5.30

自引率

3.60%

发文量

139

审稿时长

16 weeks

期刊介绍： Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.