Association between ultrasound-based biliary and parenchymal intrahepatic mass-forming cholangiocarcinoma subtypes and clinicopathological features and survival.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-06-19 DOI:10.1186/s13244-025-02019-0

Cong-Jian Wen, Hui Liu, Li-Ping Sun, Chong-Ke Zhao, Hao-Hao Yin, Li-Fan Wang, Ming-Rui Zhu, Yi-Kang Sun, Ya-Qin Zhang, Zi-Tong Chen, Xi Wang, Han-Sheng Xia, Hong Han, Hui-Xiong Xu, Bo-Yang Zhou

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引用次数: 0

Abstract

Objective: Mass-forming intrahepatic cholangiocarcinomas (MF-ICCs) can be classified into ductal and parenchymal types using magnetic resonance imaging (MRI). We aimed to subclassify MF-ICC into biliary and parenchymal types based on ultrasound (US) findings and to investigate the differences in their contrast-enhanced ultrasound (CEUS) patterns, clinicopathologic features, and prognosis.

Methods: In this study, 141 patients who underwent US with pathologically proven MF-ICC from two hospitals were retrospectively enrolled. MF-ICCs were divided into biliary (bMF-ICCs) and parenchymal MF-ICC (pMF-ICCs) based on the signs of bile duct dilation in US images. Clinicopathological, imaging, and short-term survival data were collected from medical records and compared.

Results: Among 141 patients (61.96 ± 10.15 years, 83 men), bMF-ICCs (33/141, 23.4%) showed significantly more CEA ≥ 5 µg/L (42.4% vs 20.2%, p = 0.01), microvascular invasion (54.5% vs 10.2%, p < 0.001), lymph node metastasis (48.5% vs 5.6%, p < 0.001), bile duct invasion (48.5% vs 5.6%, p < 0.001), and high Ki-67 expression (63.6% vs 38.9%, p = 0.01) than pMF-ICCs. Pathologically, bMF-ICCs were more inclined toward the large duct type (78.1% vs 11.7%, p < 0.001). In addition, the bMF-ICCs were usually located in the left lobe of the liver (63.6% vs 41.7%, p = 0.03). pMF-ICCs showed better overall survival than bMF-ICCs (p = 0.04).

Conclusions: Subclassification of MF-ICCs into biliary and parenchymal types based on US is useful for discriminating clinicopathological characteristics.

Critical relevance statement: The subclassification of mass-forming intrahepatic cholangiocarcinoma (MF-ICC) into biliary (bMF-ICC) and parenchymal (pMF-ICC) subtypes using ultrasound can provide clinicopathological and prognostic information before surgery.

Key points: We subclassified mass-forming intrahepatic cholangiocarcinomas into biliary and parenchymal types using ultrasound. Biliary and parenchymal types have different clinicopathological features and postsurgical outcomes. Biliary type above and below 50 mm exhibits different unfavorable clinicopathological characteristics. Our classification has certain similarities with MRI classification in clinicopathological characteristics.

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基于超声的胆道和实质肝内肿块形成胆管癌亚型与临床病理特征和生存之间的关系

目的：磁共振成像（MRI）可将块状肝内胆管癌（MF-ICCs）分为导管型和实质型。我们的目的是根据超声（US）结果将MF-ICC分为胆道型和实质型，并探讨它们在超声造影（CEUS）模式、临床病理特征和预后方面的差异。方法：在本研究中，回顾性纳入了来自两家医院的141例经病理证实的MF-ICC患者。根据超声图像胆管扩张的征象，将胆道内胆囊炎（MF-ICC）分为胆道内胆囊炎（bmf - icc）和实质内胆囊炎（pmf - icc）。从医疗记录中收集临床病理、影像学和短期生存数据并进行比较。结果：141例患者（61.96±10.15岁，男性83例）中，bMF-ICCs（33/141, 23.4%）的CEA≥5µg/L（42.4%比20.2%,p = 0.01）、微血管侵犯（54.5%比10.2%,p = 0.01）显著增加。结论：基于US将MF-ICCs亚分类为胆道型和实质型有助于区分临床病理特征。关键相关性声明：超声将形成团块的肝内胆管癌（MF-ICC）分为胆道（bMF-ICC）和实质（pMF-ICC）亚型，可以在手术前提供临床病理和预后信息。重点：我们利用超声将形成团块的肝内胆管癌分为胆道型和实质型。胆道型和实质型具有不同的临床病理特征和术后结果。50 mm以上及以下胆道型表现出不同的不良临床病理特征。我们的分类在临床病理特征上与MRI分类有一定的相似之处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.