Melanoma update: is a cure now in sight?

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Samrin Liaqat, Muhammad Adnan Khattak
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引用次数: 0

Abstract

Melanoma, one of the most aggressive skin cancers, poses a significant global health concern due to its high metastatic potential and resistance to conventional treatments. This review explores recent advancements in melanoma treatment, particularly the impact of targeted therapies and immunotherapies which have significantly extended survival and improved the quality of life for advanced melanoma patients. Additionally, the innovative combination and sequential strategies, with immune checkpoint inhibitors and cancer vaccines or targeted therapies against BRAF mutations, mark a promising direction. Recent advances in tumour infiltrating lymphocytes and oncolytic virus therapy and personalised cancer vaccine development are also covered, highlighting the role of precision medicine in achieving tailored, effective treatments. Despite these advancements, challenges persist, including drug resistance and the need for reliable biomarkers to predict treatment response and select patients. This review underscores the ongoing efforts in research and clinical trials to refine therapeutic strategies, improve treatment outcomes for a larger population detection and, ultimately, advance towards a cure for melanoma.

黑色素瘤最新进展:治愈方法在望吗?
黑色素瘤是最具侵袭性的皮肤癌之一,由于其高转移潜力和对传统治疗的耐药性,引起了全球重大的健康问题。本文综述了黑色素瘤治疗的最新进展,特别是靶向治疗和免疫治疗的影响,这些治疗显著延长了晚期黑色素瘤患者的生存期,提高了患者的生活质量。此外,免疫检查点抑制剂和癌症疫苗或针对BRAF突变的靶向治疗的创新组合和顺序策略标志着一个有希望的方向。还介绍了肿瘤浸润淋巴细胞和溶瘤病毒治疗以及个性化癌症疫苗开发的最新进展,突出了精准医学在实现量身定制的有效治疗方面的作用。尽管取得了这些进步,但挑战依然存在,包括耐药和需要可靠的生物标志物来预测治疗反应和选择患者。这篇综述强调了研究和临床试验正在进行的努力,以完善治疗策略,改善治疗结果,以实现更大的人群检测,并最终朝着治愈黑色素瘤的方向发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Internal Medicine Journal
Internal Medicine Journal 医学-医学:内科
CiteScore
3.50
自引率
4.80%
发文量
600
审稿时长
3-6 weeks
期刊介绍: The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.
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