Cirrhotic Cardiomyopathy: Prevalence and Clinical Impact on Liver Cirrhosis Outcomes.

IF 3.9 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Takashi Kitagataya, Goki Suda, Takatsugu Tanaka, Shoichi Kitano, Naohiro Yasuura, Akimitsu Meno, Takashi Sasaki, Risako Kohya, Qingjie Fu, Shunichi Hosoda, Sonoe Yoshida, Osamu Maehara, Shunsuke Ohnishi, Masatsugu Ohara, Masato Nakai, Takuya Sho, Kosuke Nakamura, Suguru Ishizaka, Naoya Sakamoto
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引用次数: 0

Abstract

Aim: Cirrhotic cardiomyopathy (CCM) is a significant complication of liver cirrhosis; however, its prevalence and impact in Asian populations remain unclear. The aim of this study was to assess the prevalence of CCM in Japanese patients with liver cirrhosis and to evaluate its impact on clinical outcomes.

Methods: In this retrospective study, 80 patients with liver cirrhosis confirmed using transient elastography (liver stiffness ≥ 12.5 kPa) were included. Study was performed at Hokkaido University Hospital between January 2014 and April 2024. CCM was diagnosed using the 2019 Cirrhotic Cardiomyopathy Consortium criteria. Subsequently, patient characteristics, survival, and the incidences of decompensation and cardiovascular events were analyzed.

Results: The prevalence of CCM was 46.3% (37/80), with 78.4% of patients with CCM showing isolated systolic dysfunction based on global longitudinal strain. Patients with CCM were significantly older, had lower serum ammonia and bilirubin levels, and had higher platelet counts. CCM was associated with a significantly higher incidence of decompensation events (hazard ratio 3.97, 95% confidence interval 1.64-9.61, p = 0.003) and was an independent risk factor for decompensation in the multivariate analysis (hazard ratio 3.24, 95% confidence interval 1.29-8.11, p = 0.012). Patients with and without CCM showed no significant differences in overall survival or cardiovascular events.

Conclusions: CCM is prevalent among Japanese patients with liver cirrhosis and is associated with an increased risk of hepatic decompensation. These findings highlight the importance of cardiac evaluation in patients with cirrhosis and suggest that CCM should be considered in the management of liver cirrhosis to improve patient outcomes.

肝硬化心肌病:患病率和对肝硬化结局的临床影响。
目的:肝硬化心肌病(CCM)是肝硬化的重要并发症;然而,其在亚洲人群中的流行程度和影响尚不清楚。本研究的目的是评估日本肝硬化患者CCM的患病率,并评估其对临床结果的影响。方法:回顾性研究80例经瞬时弹性成像(肝硬度≥12.5 kPa)证实的肝硬化患者。研究于2014年1月至2024年4月在北海道大学医院进行。CCM是根据2019年肝硬化心肌病协会标准诊断的。随后,对患者特征、生存率、失代偿和心血管事件发生率进行分析。结果:CCM的患病率为46.3%(37/80),其中78.4%的CCM患者基于整体纵向应变表现孤立性收缩功能障碍。CCM患者明显年龄较大,血清氨和胆红素水平较低,血小板计数较高。CCM与失代偿事件发生率显著升高相关(风险比3.97,95%可信区间1.64 ~ 9.61,p = 0.003),在多因素分析中,CCM是失代偿的独立危险因素(风险比3.24,95%可信区间1.29 ~ 8.11,p = 0.012)。有和没有CCM的患者在总生存期和心血管事件方面没有显著差异。结论:CCM在日本肝硬化患者中普遍存在,并与肝失代偿风险增加相关。这些发现强调了肝硬化患者心脏评估的重要性,并建议在肝硬化治疗中应考虑CCM以改善患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hepatology Research
Hepatology Research 医学-胃肠肝病学
CiteScore
8.30
自引率
14.30%
发文量
124
审稿时长
1 months
期刊介绍: Hepatology Research (formerly International Hepatology Communications) is the official journal of the Japan Society of Hepatology, and publishes original articles, reviews and short comunications dealing with hepatology. Reviews or mini-reviews are especially welcomed from those areas within hepatology undergoing rapid changes. Short communications should contain concise definitive information.
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