Polymorphisms in circadian rhythm genes and the risk of differentiated thyroid cancer.

IF 2.8 3区生物学 Q2 GENETICS & HEREDITY

Frontiers in Genetics Pub Date : 2025-06-04 eCollection Date: 2025-01-01 DOI:10.3389/fgene.2025.1539090

Takiy-Eddine Berrandou, Emilie Cordina-Duverger, Claire Mulot, Anne-Valérie Guizard, Claire Schvartz, Pierre Laurent-Puig, Monia Zidane, Florent De Vathaire, Pascal Guénel, Thérèse Truong

{"title":"Polymorphisms in circadian rhythm genes and the risk of differentiated thyroid cancer.","authors":"Takiy-Eddine Berrandou, Emilie Cordina-Duverger, Claire Mulot, Anne-Valérie Guizard, Claire Schvartz, Pierre Laurent-Puig, Monia Zidane, Florent De Vathaire, Pascal Guénel, Thérèse Truong","doi":"10.3389/fgene.2025.1539090","DOIUrl":null,"url":null,"abstract":"Introduction: Circadian rhythms are controlled by biological clocks regulated at the molecular level by a set of circadian genes operating through a negative feedback loop. These genes also regulate key biological processes, including cell proliferation, cell cycle, and apoptosis.Methods: We investigated the role of circadian gene polymorphisms in the risk of differentiated thyroid cancer (DTC) and their interaction with DTC risk factors. Data were obtained from 463 DTC cases and 482 unrelated controls of European ancestry, selected from two population-based case-control studies conducted in France. Associations with 570 single nucleotide polymorphisms (SNPs) in 23 circadian genes were evaluated using multivariate logistic regression models. Gene- and pathway-level associations and gene-environment interactions were analyzed using the adaptive rank truncated product (ARTP) method.Results and discussion: We found no significant association between DTC risk and circadian gene polymorphisms at the SNP, gene, or pathway levels. However, we observed statistically significant interactions between smoking status and SNPs rs11204897 (RORC) and rs1012477 (PER3), as well as with the PER3 gene and the overall circadian pathway. These results suggest that smoking status may modulate the association between DTC and polymorphisms in circadian genes. Further studies are needed to confirm these findings.","PeriodicalId":12750,"journal":{"name":"Frontiers in Genetics","volume":"16 ","pages":"1539090"},"PeriodicalIF":2.8000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174421/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fgene.2025.1539090","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Circadian rhythms are controlled by biological clocks regulated at the molecular level by a set of circadian genes operating through a negative feedback loop. These genes also regulate key biological processes, including cell proliferation, cell cycle, and apoptosis.

Methods: We investigated the role of circadian gene polymorphisms in the risk of differentiated thyroid cancer (DTC) and their interaction with DTC risk factors. Data were obtained from 463 DTC cases and 482 unrelated controls of European ancestry, selected from two population-based case-control studies conducted in France. Associations with 570 single nucleotide polymorphisms (SNPs) in 23 circadian genes were evaluated using multivariate logistic regression models. Gene- and pathway-level associations and gene-environment interactions were analyzed using the adaptive rank truncated product (ARTP) method.

Results and discussion: We found no significant association between DTC risk and circadian gene polymorphisms at the SNP, gene, or pathway levels. However, we observed statistically significant interactions between smoking status and SNPs rs11204897 (RORC) and rs1012477 (PER3), as well as with the PER3 gene and the overall circadian pathway. These results suggest that smoking status may modulate the association between DTC and polymorphisms in circadian genes. Further studies are needed to confirm these findings.

查看原文本刊更多论文

昼夜节律基因多态性与分化型甲状腺癌的风险。

生物昼夜节律是由生物钟控制的，生物钟在分子水平上由一组昼夜节律基因通过负反馈回路进行调控。这些基因还调节关键的生物过程，包括细胞增殖、细胞周期和细胞凋亡。方法：研究昼夜节律基因多态性在分化型甲状腺癌（DTC）发病中的作用及其与DTC危险因素的相互作用。数据来自在法国进行的两项基于人群的病例对照研究，选取了463例DTC病例和482例无血缘关系的欧洲血统对照。使用多变量logistic回归模型评估了23个昼夜节律基因中570个单核苷酸多态性（snp）的相关性。采用自适应秩截断积（ARTP）方法分析了基因和途径水平的关联以及基因与环境的相互作用。结果和讨论：我们发现在SNP、基因或通路水平上，DTC风险与昼夜节律基因多态性之间没有显著关联。然而，我们观察到吸烟状况与snp rs11204897 （RORC）和rs1012477 (PER3)，以及PER3基因和整个昼夜节律通路之间存在统计学上显著的相互作用。这些结果表明，吸烟状态可能调节DTC与昼夜节律基因多态性之间的关系。需要进一步的研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

5.50

自引率

8.10%

发文量

3491

审稿时长

14 weeks

期刊介绍： Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.