The role of MBD2 in immune cell development, function, and autoimmune diseases.

IF 7 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-06-19 DOI:10.1038/s41420-025-02563-0

Yunfei Zhang, Yufeng Fan, Ying Hu, Xiaocui Wang, Bin Wen, Xuemei Duan, Haonan Li, Shumin Dong, Ze Yan, Weiwei Zhang, Yukai Jing

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Abstract

DNA methylation is a key epigenetic modification that regulates gene expression, cell differentiation, and genome stability. Aberrant DNA methylation patterns, including the hypermethylation or global hypomethylation of tumor suppressor genes, are strongly associated with various human diseases, such as cancer, autoimmune disorders, and metabolic syndrome. DNA methylation predominantly occurs at CpG dinucleotides, influencing transcription by altering chromatin structure and accessibility. MBD2 (Methyl-CpG-binding proteins 2) play a crucial role in interpreting these epigenetic marks and regulating downstream gene expression. In disease contexts, aberrant DNA methylation disrupts cellular homeostasis by silencing key regulatory genes or activating pathological pathways. Current research primarily focuses on MBD2 in cancer, with less emphasis on its role in autoimmune diseases. This review discusses the role of MBD2 in regulating immune cell development and differentiation through epigenetic mechanisms, particularly DNA methylation and its regulatory components. Furthermore, it highlights the mechanistic contributions of MBD2 to autoimmune diseases such as systemic lupus erythematosus and evaluates its potential as a novel therapeutic target for these conditions.

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MBD2在免疫细胞发育、功能和自身免疫性疾病中的作用。

DNA甲基化是调控基因表达、细胞分化和基因组稳定性的关键表观遗传修饰。异常的DNA甲基化模式，包括肿瘤抑制基因的超甲基化或整体低甲基化，与各种人类疾病，如癌症、自身免疫性疾病和代谢综合征密切相关。DNA甲基化主要发生在CpG二核苷酸上，通过改变染色质结构和可及性来影响转录。MBD2（甲基- cpg结合蛋白2）在解释这些表观遗传标记和调节下游基因表达中起着至关重要的作用。在疾病背景下，异常DNA甲基化通过沉默关键调控基因或激活病理通路来破坏细胞稳态。目前的研究主要集中在MBD2在癌症中的作用，较少强调其在自身免疫性疾病中的作用。本文综述了MBD2通过表观遗传机制，特别是DNA甲基化及其调控组分在调节免疫细胞发育和分化中的作用。此外，该研究强调了MBD2对自身免疫性疾病（如系统性红斑狼疮）的机制贡献，并评估了其作为这些疾病的新治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.