Endotoxin, Virus and Bacterial Removal: Why, When and How?

IF 2.2 3区医学 Q3 HEMATOLOGY

Blood Purification Pub Date : 2025-06-18 DOI:10.1159/000546923

Lui G Forni, Vedran Premuzic

引用次数: 0

Abstract

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection and where underlying circulatory, cellular, and metabolic abnormalities contribute to a greater risk of mortality than that posed by sepsis alone this may be considered septic shock where circulatory support is needed in the face of a raised lactate level. The main pillars of therapy remain source control and appropriate timely antibiotics, resuscitation where needed and adequate source control. However in the setting of organ failure further support may be needed. Here we discuss the potential benefits from removal of pathogens using available extracorporeal techniques. Although randomised controlled trials supporting such an approach are remin elusive this is due to change in the next few years with current studies being performed.

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去除内毒素、病毒和细菌：为什么、何时以及如何去除？

脓毒症被定义为一种危及生命的器官功能障碍，由宿主对感染的反应失调引起，其中潜在的循环、细胞和代谢异常比脓毒症本身造成的死亡风险更大，这可能被认为是脓毒症休克，在乳酸水平升高时需要循环支持。治疗的主要支柱仍然是源头控制和适当及时的抗生素，必要时的复苏和充分的源头控制。然而，在器官衰竭的情况下，可能需要进一步的支持。在这里，我们讨论使用可用的体外技术去除病原体的潜在好处。尽管支持这种方法的随机对照试验仍然难以捉摸，但这是由于未来几年随着当前研究的进行而发生变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Purification 医学-泌尿学与肾脏学

CiteScore

5.80

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Practical information on hemodialysis, hemofiltration, peritoneal dialysis and apheresis is featured in this journal. Recognizing the critical importance of equipment and procedures, particular emphasis has been placed on reports, drawn from a wide range of fields, describing technical advances and improvements in methodology. Papers reflect the search for cost-effective solutions which increase not only patient survival but also patient comfort and disease improvement through prevention or correction of undesirable effects. Advances in vascular access and blood anticoagulation, problems associated with exposure of blood to foreign surfaces and acute-care nephrology, including continuous therapies, also receive attention. Nephrologists, internists, intensivists and hospital staff involved in dialysis, apheresis and immunoadsorption for acute and chronic solid organ failure will find this journal useful and informative. ''Blood Purification'' also serves as a platform for multidisciplinary experiences involving nephrologists, cardiologists and critical care physicians in order to expand the level of interaction between different disciplines and specialities.