Impact of extracellular matrix scaffold on driveline infection rate in patients with left ventricular assist devices

IF 1.9

JTCVS open Pub Date : 2025-06-01 DOI:10.1016/j.xjon.2025.03.029

Mehmet H. Akay MD, Mateja K. Jezovnik MD, PhD, Rajko Radovancevic MD, Ismael A. Salas de Armas MD, Maria Patarroyo Aponte MD, Marwan Jumean MD, Manish K. Patel MD, Jayeshkumar Patel MD, Biswajit Kar MD, Igor D. Gregoric MD

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Abstract

Objective

Left ventricular assist device (LVAD) implantation is a life-saving procedure for patients with advanced heart failure. However, postimplantation complications such as driveline infections (DLIs) can significantly affect patient outcomes. We assessed whether placing an extracellular matrix (ECM) scaffold around the driveline during LVAD implantation reduces the incidence of DLIs in patients with LVADs.

Methods

This retrospective observational study included 196 consecutive patients with LVADs between January 2018 and June 2022. We compared the data of patients who received ECM implantation during LVAD implantation (ECM group, n = 69) with those who did not (control group, n = 127).

Results

During the study period, 24 of 196 (12.2%) patients with LVADs developed a DLI. Patients who underwent ECM placement exhibited a significantly lower incidence of DLIs than those in the control group (ECM 3/69 vs control 21/127; P = .012).

Conclusions

Patients who received ECM implantation at the time of LVAD implantation had a significantly lower rate of DLIs than patients who did not receive ECM around the driveline. These results suggest that ECM may be a valuable adjunctive strategy to reduce the risk of DLIs in LVAD recipients.

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细胞外基质支架对左心室辅助装置患者传动系统感染率的影响

目的左心室辅助装置（LVAD）植入术是晚期心力衰竭患者的救命手段。然而，植入后并发症，如传动系统感染（DLIs）可以显著影响患者的预后。我们评估了在LVAD植入期间在传动系周围放置细胞外基质（ECM）支架是否可以降低LVAD患者的DLIs发生率。方法本回顾性观察研究纳入了2018年1月至2022年6月期间连续196例lvad患者。我们比较了LVAD植入期间接受ECM植入的患者（ECM组，n = 69）和未接受ECM植入的患者（对照组，n = 127）的数据。结果在研究期间，196例lvad患者中有24例（12.2%）发生了DLI。植入ECM的患者的DLIs发生率明显低于对照组(ECM 3/69 vs对照组21/127；P = .012)。结论在LVAD植入时接受ECM的患者，其DLIs发生率明显低于未接受驱动系周围ECM的患者。这些结果表明，ECM可能是一种有价值的辅助策略，可以降低LVAD受者的DLIs风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JTCVS open

CiteScore

1.70

自引率

0.00%

发文量