Sociodemographically differential patterns of chronic pain progression revealed by analyzing the all of us research program data.

PLOS digital health Pub Date : 2025-06-17 eCollection Date: 2025-06-01 DOI:10.1371/journal.pdig.0000687
Edwin Baldwin, Jin Zhou, Wenting Luo, W Michael Hooten, Jungwei W Fan, Haiquan Li
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Abstract

The differential progression of ten chronic overlapping pain conditions (COPC) and four comorbid mental disorders across demographic groups have rarely been reported in the literature. To fill in this gap, we conducted retrospective cohort analyses using All of Us Research Program data from 1970 to 2023. Separate cohorts were created to assess the differential patterns across sex, race, and ethnicity. Logistic regression models, controlling for demographic variables and household income level, were employed to identify significant sociodemographic factors associated with the differential progression from one COPC or mental condition to another. Among the 139 frequent disease pairs, we identified group-specific patterns in 15 progression pathways. Black or African Americans with a COPC condition had a significantly increased association in progression to other COPCs (CLBP- > IBS, CLBP- > MHA, or IBS- > MHA, OR≥1.25, adj.p ≤ 4.0x10-3) or mental disorders (CLBP- > anxiety, CLBP- > depression, MHA- > anxiety, MHA- > depression, OR≥1.25, adj.p ≤ 1.9x10-2) after developing a COPC. Females had an increased likelihood of chronic low back pain after anxiety and depression (OR≥1.12, adj.p ≤ 1.5x10-2). Additionally, the lowest income bracket was associated with an increased risk of developing another COPC from a COPC (CLBP- > MHA, IBS- > MHA, MHA- > CLBP, or MHA- > IBS, OR≥1.44, adj.p ≤ 2.6x10-2) or from a mental disorder (depression- > MHA, depression- > CLBP, anxiety- > CLBP, or anxiety- > IBS, OR≥1.50, adj.p ≤ 2.0x10-2), as well as developing a mental disorder after a COPC (CLBP- > depression, CBLP- > anxiety, MHA- > anxiety, OR≥1.37,adj.p ≤ 1.6x10-2). To our knowledge, this is the first study that unveils the sociodemographic influence on COPC progression. These findings suggest the importance of considering sociodemographic factors to achieve optimal prognostication and preemptive management of COPCs.

通过分析我们所有的研究项目数据揭示了慢性疼痛进展的社会人口统计学差异模式。
十种慢性重叠疼痛状况(COPC)和四种共病精神障碍在人口统计学群体中的差异进展在文献中很少报道。为了填补这一空白,我们使用1970年至2023年的All of Us Research Program数据进行了回顾性队列分析。建立了单独的队列来评估性别、种族和民族之间的差异模式。采用Logistic回归模型,控制人口变量和家庭收入水平,以确定与从一种COPC或精神状况到另一种COPC或精神状况的差异进展相关的重要社会人口因素。在139对常见疾病中,我们确定了15种进展途径的群体特异性模式。患有COPC的黑人或非裔美国人在发生COPC后发展为其他COPC (CLBP- > IBS、CLBP- > MHA或IBS- > MHA, or≥1.25,adj.p≤4.0 × 10-3)或精神障碍(CLBP- >焦虑、CLBP- >抑郁、MHA- >焦虑、MHA- >抑郁,or≥1.25,adj.p≤1.9 × 10-2)的相关性显著增加。女性在焦虑和抑郁后出现慢性腰痛的可能性增加(OR≥1.12,aj .p≤1.5x10-2)。此外,最低收入阶层与COPC (CLBP- > MHA, IBS- > MHA, MHA- > CLBP或MHA- > IBS, or≥1.44,adj.p≤2.6 × 10-2)或精神障碍(抑郁- > MHA,抑郁- > CLBP,焦虑- > CLBP或焦虑- > IBS, or≥1.50,adj.p≤2.0 × 10-2)以及COPC后发生精神障碍(CLBP- >抑郁,CBLP- >焦虑,MHA- >焦虑,or≥1.37,adj.p≤1.6 × 10-2)相关。据我们所知,这是第一个揭示社会人口统计学对COPC进展影响的研究。这些研究结果表明,考虑社会人口因素对于实现COPCs的最佳预测和先发制人管理的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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