Genetic profiling and precision skin care: a review.

IF 2.8 3区生物学 Q2 GENETICS & HEREDITY

Frontiers in Genetics Pub Date : 2025-06-03 eCollection Date: 2025-01-01 DOI:10.3389/fgene.2025.1559510

Barbara Geusens, Diala Haykal

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引用次数: 0

Abstract

Skin aging is a multifaceted biological phenomenon driven by intrinsic and extrinsic factors, including genetics, hormonal changes, metabolic shifts, and environmental influences. Notably, genetic factors play a significant role, explaining up to 60% of the variability in how individuals age. Genes such as elastin (ELN), filaggrin (FLG), and melanocortin 1 receptor (MC1R) play pivotal roles in processes like elasticity, hydration, and pigmentation, directly impacting both intrinsic and extrinsic aging pathways. Understanding these genetic mechanisms is crucial for advancing personalized anti-aging products and therapies, particularly given the significant variability among individuals and ethnic groups. This review explores the current state of knowledge regarding the genetic determinants of skin aging, highlighting recent discoveries and proposing functional pathways for targeted interventions. Future directions are discussed to highlight the transformative potential of these innovations in clinical and aesthetic dermatology. While genetic factors may account for up to 60% of skin aging variability in specific populations, this figure should be interpreted with caution. It primarily reflects heritability under controlled conditions and does not negate the significant influence of modifiable lifestyle and environmental factors on skin and overall aging.

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基因分析与精确皮肤护理：综述。

皮肤老化是一种由内在和外在因素驱动的多方面生物现象，包括遗传、激素变化、代谢变化和环境影响。值得注意的是，遗传因素发挥了重要作用，解释了个人年龄变化的60%。弹性蛋白（ELN）、聚丝蛋白（FLG）和黑素皮质素1受体（MC1R）等基因在弹性、水合作用和色素沉着等过程中起着关键作用，直接影响内在和外在的衰老途径。了解这些遗传机制对于推进个性化抗衰老产品和治疗至关重要，特别是考虑到个体和种族群体之间的显著差异。这篇综述探讨了目前关于皮肤衰老的遗传决定因素的知识状况，突出了最近的发现，并提出了有针对性的干预措施的功能途径。未来的方向进行了讨论，以突出这些创新在临床和美容皮肤科的变革潜力。虽然遗传因素可能占特定人群皮肤衰老变异性的60%，但这一数字应谨慎解释。它主要反映了受控条件下的遗传性，并不能否定可改变的生活方式和环境因素对皮肤和整体衰老的显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

5.50

自引率

8.10%

发文量

3491

审稿时长

14 weeks

期刊介绍： Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.