Endogenous opiates and behavior: 2024

IF 2.8 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Peptides Pub Date : 2025-06-16 DOI:10.1016/j.peptides.2025.171422

Richard J. Bodnar

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引用次数: 0

Abstract

This paper is the forty-seventh consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2024 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).

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内源性阿片类药物与行为：2024

这篇论文是关于内源性阿片系统研究的连续第47期年度综述，总结了2024年发表的关于阿片肽和受体的分子、药理学和遗传操纵的行为影响以及阿片/阿片激动剂和拮抗剂作用的文章。本检讨分为以下若干专题：内源性阿片及其受体的分子生化效应和神经化学定位研究(1)，这些阿片肽和受体在动物疼痛和镇痛中的作用(2)和人类(3)，非阿片镇痛药的阿片敏感和阿片不敏感作用(4)，阿片肽和受体参与耐受性和依赖性(5)，压力和社会地位(6)，学习和记忆(7)，饮食(8)，药物滥用和酒精(9)，性活动和激素、怀孕、发育和内分泌学（10）、精神疾病和情绪（11）、癫痫和神经系统疾病（12）、电相关活动和神经生理学（13）、一般活动和运动（14）、胃肠道、肾脏和肝脏功能（15）、心血管反应（16）、呼吸和体温调节（17）、免疫反应（18）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Peptides 医学-生化与分子生物学

CiteScore

6.40

自引率

6.70%

发文量

130

审稿时长

28 days

期刊介绍： Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.