The value of systematic study and biobanking of explanted hearts: Insights from an international ISHLT pathology survey

JHLT Open Pub Date : 2025-05-30 DOI:10.1016/j.jhlto.2025.100306

Marny Fedrigo MD PhD , Diego Perazzolo Ing , Gerald J. Berry MD , Annalisa Angelini MD

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Abstract

This study evaluates global practices for managing explanted hearts, with a focus on tissue collection and biobanking protocols. A survey conducted through the International Society for Heart and Lung Transplantation (ISHLT) assessed responses from centers across Europe, North America, and Other Countries. Results demonstrated significant variability in tissue sampling, grossing protocols, and storage practices. While 78.8% of centers had grossing protocols, fewer (73.1%) adapted sampling based on pathology. Fresh tissue collection was prevalent in 63.5% of centers, but volumes varied: North America led with higher sampling rates (10-25 samples per heart), while Europe and Other Countries collected fewer samples. Coronary artery sampling also showed regional differences. Fresh tissues enable advanced molecular studies, while fixed tissues remain fundamental for histopathology. Standardized global protocols for sampling, storage, and reporting could enhance the clinical and research value of explanted hearts, optimizing post-transplant care and driving innovation in cardiac medicine.

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系统研究和外植心脏生物库的价值：来自国际ISHLT病理学调查的见解

本研究评估了管理外植心脏的全球实践，重点是组织收集和生物银行协议。通过国际心肺移植学会（ISHLT）进行的一项调查评估了来自欧洲、北美和其他国家中心的反应。结果表明，在组织取样、总收入方案和储存实践方面存在显著差异。虽然78.8%的中心有总体方案，但较少（73.1%）的中心采用基于病理的抽样。新鲜纸巾采集在63.5%的中心普遍存在，但数量各不相同：北美的采样率较高（每心脏10-25个样本），而欧洲和其他国家收集的样本较少。冠状动脉采样也显示出地区差异。新鲜组织可以进行高级分子研究，而固定组织仍然是组织病理学的基础。标准化的取样、储存和报告的全球协议可以提高移植心脏的临床和研究价值，优化移植后护理，推动心脏医学的创新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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JHLT Open

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