[Recent progress in the regulation of cellular immunity to erythrocyte homologous immunity].

细胞与分子免疫学杂志 Pub Date : 2025-06-01
Woxia Hong, Changlin Wu, Chaopeng Shao
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引用次数: 0

Abstract

Chronic anemia patients (such as thalassemia) often rely on long-term red blood cell transfusion to sustain life. However, alloimmune reactions against blood group antigens can pose serious risks to the patients' clinical treatment and survival. The regulatory mechanisms of transfusion-related alloimmunity are not yet well understood. For example, some patients, despite long-term transfusions, do not develop alloimmune reactions, while others produce alloantibodies against multiple blood group antigens, making transfusion therapy increasingly difficult. Red blood cell blood group alloimmunity involves various immune cells, including antigen-presenting cells and different T cells. Many studies are exploring the regulatory roles and even potential interventions. This article reviews the correlation between cellular immunity and red blood cell blood group antigens in alloimmune responses, and explores the interaction between the two, as well as their impact on immune responses.

细胞免疫对红细胞同源免疫调控的最新进展。
慢性贫血患者(如地中海贫血)往往依赖长期的红细胞输注来维持生命。然而,针对血型抗原的同种免疫反应会给患者的临床治疗和生存带来严重的风险。输血相关同种免疫的调节机制尚不清楚。例如,一些患者尽管长期输血,但不会产生同种免疫反应,而另一些患者则产生针对多种血型抗原的同种抗体,这使得输血治疗越来越困难。红细胞血型同种免疫涉及多种免疫细胞,包括抗原呈递细胞和不同的T细胞。许多研究正在探索调节作用甚至潜在的干预措施。本文综述了同种免疫反应中细胞免疫与红细胞血型抗原的关系,并探讨了两者之间的相互作用,以及它们对免疫反应的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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