Effect of the Residual Errors on the Dose for Left-Sided Breast Cancer Radiotherapy After Translation Error Correction Based on CBCT.

IF 2.8 4区 医学 Q3 ONCOLOGY
Technology in Cancer Research & Treatment Pub Date : 2025-01-01 Epub Date: 2025-06-17 DOI:10.1177/15330338251338489
Ya Wang, Lu Zeng, Pan Gong, Denghong Liu, Qianqian Meng, Konglong Shen, Zhihui Liu, Renming Zhong
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引用次数: 0

Abstract

ObjectiveThis study analyzed the dosimetric impact of residual errors (rotational and deformation errors) in left-sided breast cancer radiotherapy after cone-beam CT (CBCT)-based translational errors correction.MethodsTwenty patients treated with intensity-modulated radiotherapy (IMRT) were retrospectively analyzed. Virtual CT images were generated by deforming and registering CBCT images with planning CT images. The accumulated dose was calculated to assess residual errors effects on target and organs at risk (OARs). A phantom test was conducted to evaluate rotational errors impacts.ResultsResults showed significant dose differences: for 4005 cGy, D98 and D95 of the breast (PTVb) decreased, and mean dose, V30, and V20 of the left lung reduced; for 5000 cGy, D98 of the supraclavicular lymph nodes (PTVsc) and PTVb, D95 of PTVb, and mean dose and V20 of the heart differed significantly. Phantom simulations revealed that pitch angles ≤-1.8° and roll/yaw angles >2° caused overdosing in the left lung and heart, with maximum dose differences of 31.89% (heart) and 19.19% (lung) for 4005 cGy, and 26.32% (heart) and 20.92% (PTVsc) for 5000 cGy.ConclusionResidual errors significantly affect dose distribution despite CBCT-based translational correction. Improved immobilization techniques or 6DOF couch correction are recommended to mitigate rotational errors.

Abstract Image

Abstract Image

Abstract Image

基于CBCT的平移误差校正后残留误差对左侧乳腺癌放疗剂量的影响。
目的分析基于锥束CT (cone-beam CT, CBCT)的平移误差校正后残留误差(旋转和变形误差)对左侧乳腺癌放疗的剂量学影响。方法回顾性分析20例调强放疗患者的临床资料。通过对规划CT图像进行变形配准,生成虚拟CT图像。计算累积剂量以评估残余误差对靶和危险器官(OARs)的影响。进行了模拟试验来评估旋转误差的影响。结果剂量差异有统计学意义:4005 cGy组乳腺(PTVb) D98、D95降低,左肺平均剂量、V30、V20降低;5000 cGy时,锁骨上淋巴结(PTVsc)和PTVb的D98、PTVb的D95、心脏的平均剂量和V20差异有统计学意义。模拟结果显示,俯仰角≤-1.8°和横摇/偏航角>°导致左肺和心脏过量,4005 cGy时最大剂量差值为31.89%(心脏)和19.19%(肺),5000 cGy时最大剂量差值为26.32%(心脏)和20.92% (PTVsc)。结论尽管基于cbct的平移校正,但残留误差对剂量分布有显著影响。改良的固定技术或6DOF沙发矫正建议减轻旋转误差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
202
审稿时长
2 months
期刊介绍: Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.
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