Chronic Hepatitis C Treatment Failure With Crushed Sofosbuvir/Velpatasvir in a Patient With Total Parenteral Nutrition-dependent Short Bowel Syndrome.

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Noelle E Nelson
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引用次数: 0

Abstract

We present the case of a 61-year-old patient infected with chronic hepatitis C virus (HCV) genotype 3, F1 fibrosis and history of short bowel syndrome, dependent on total parenteral nutrition (TPN) who was referred to the clinical pharmacist for HCV treatment. Following 12 weeks of treatment with crushed, orally administered sofosbuvir/velpatasvir (SOF/VEL) the patient was unable to achieve sustained virologic response (SVR12), suggesting that this therapy may be ineffective in patients with short bowel syndrome.

索非布韦/维帕他韦粉碎治疗全肠外营养依赖性短肠综合征患者慢性丙型肝炎失败
我们报告了一例61岁的慢性丙型肝炎病毒(HCV)基因型3感染患者,F1纤维化和短肠综合征病史,依赖于全肠外营养(TPN),他被推荐给临床药剂师进行HCV治疗。在口服sofosbuvir/velpatasvir (SOF/VEL)碾碎治疗12周后,患者无法达到持续病毒学应答(SVR12),这表明该疗法对短肠综合征患者可能无效。
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来源期刊
Journal of pharmacy practice
Journal of pharmacy practice PHARMACOLOGY & PHARMACY-
CiteScore
3.20
自引率
7.70%
发文量
184
期刊介绍: The Journal of Pharmacy Practice offers the practicing pharmacist topical, important, and useful information to support pharmacy practice and pharmaceutical care and expand the pharmacist"s professional horizons. The journal is presented in a single-topic, scholarly review format. Guest editors are selected for expertise in the subject area, who then recruit contributors from that practice or topic area.
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