Relationships Between Nutrition Risk and Frailty in Candidates for Lung Transplant

IF 1.9 4区医学 Q2 SURGERY

Clinical Transplantation Pub Date : 2025-06-18 DOI:10.1111/ctr.70205

Brooke Stewart, Rebecca Brody, Hamed Samavat, Laura Byham-Gray, Noori Chowdhury, Sunita Mathur, Lianne G. Singer

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引用次数: 0

Abstract

Background

Healthcare teams evaluating candidates for lung transplant seek to identify and address modifiable factors to improve their clinical outcomes. Frailty may be a modifiable factor, and poor nutrition may be a contributor to frailty. This study evaluated the relationship between nutrition risk and frailty in lung transplant candidates.

Methods

This was a secondary analysis of data from 62 adult lung transplant candidates. Nutrition risk was assessed with the Seniors in the Community: Risk Evaluation for Eating and Nutrition (SCREEN-14) questionnaire, and frailty was measured using two methods: physical frailty with the Fried frailty index (FFI) and multidimensional frailty using a cumulative deficits frailty index (CDFI), where higher scores on a 0–1 scale denote increasing frailty. Pearson correlation, independent-samples t-test, and Fisher's exact tests analyzed associations between SCREEN-14 and both FFI and CDFI scores.

Results

Most participants were at high nutrition risk (83.9%) and were pre-frail (69.4%) or frail (17.7%) when assessed using FFI. Mean CDFI score was 0.26. Higher nutrition risk was associated with a higher degree of frailty as measured using FFI (r = −0.303; p = 0.017) but not CDFI. Participants at high nutrition risk were significantly more likely to be pre-frail or frail by FFI than those at low nutrition risk (92.3% vs. 60.0%, respectively; p = 0.019).

Conclusions

High nutrition risk is highly prevalent and associated with physical frailty in lung transplant candidates. Future studies should investigate how to best identify nutrition risk and whether interventions that reduce this risk also decrease frailty.

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肺移植候选者营养风险与虚弱的关系

背景：医疗团队评估肺移植候选者寻求识别和处理可改变的因素，以改善其临床结果。虚弱可能是一个可改变的因素，而营养不良可能是导致虚弱的一个因素。本研究评估了营养风险与肺移植候选人虚弱之间的关系。方法对62例成人肺移植候选者的资料进行二次分析。通过社区老年人：饮食和营养风险评估（SCREEN-14）问卷评估营养风险，并使用两种方法测量脆弱性：使用Fried脆弱性指数（FFI）的身体脆弱性和使用累积缺陷脆弱性指数（CDFI）的多维脆弱性，其中0-1的分数越高表示脆弱性增加。Pearson相关、独立样本t检验和Fisher精确检验分析了SCREEN-14与FFI和CDFI评分之间的关系。结果当使用FFI评估时，大多数参与者处于高营养风险（83.9%），虚弱前（69.4%）或虚弱（17.7%）。平均CDFI评分为0.26。高营养风险与高虚弱程度相关，使用FFI测量(r = - 0.303；p = 0.017)，但CDFI没有。高营养风险的参与者比低营养风险的参与者更容易因FFI而体弱或虚弱(分别为92.3%对60.0%；P = 0.019)。结论高营养风险在肺移植候选者中非常普遍，并与身体虚弱相关。未来的研究应该调查如何最好地识别营养风险，以及减少这种风险的干预措施是否也能减少虚弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Transplantation 医学-外科

CiteScore

3.70

自引率

4.80%

发文量

286

审稿时长

2 months

期刊介绍： Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored. Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include: Immunology and immunosuppression; Patient preparation; Social, ethical, and psychological issues; Complications, short- and long-term results; Artificial organs; Donation and preservation of organ and tissue; Translational studies; Advances in tissue typing; Updates on transplant pathology;. Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries. Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.