Analysis of Demographic Associations and Survival Outcomes in Patients With Colorectal Cancer at a Tertiary Care Hospital in Pakistan. A Retrospective Cross-Sectional Study.

IF 2.5 4区 医学 Q3 ONCOLOGY
Cancer Control Pub Date : 2025-01-01 Epub Date: 2025-06-15 DOI:10.1177/10732748251351423
Muhammad Osama, Hira Moosa, Hussain Sohail Rangwala, Burhanuddin Sohail Rangwala, Ayesha Farrukh, Sakeena Fayaz, Muhammad Nalwala, Muhammad Ashir Shafique, Mazhar Iqbal
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引用次数: 0

Abstract

IntroductionColorectal cancer (CRC) is the third most common cancer worldwide, with higher rates in industrialized countries. By 2030, the number of CRC cases may rise by 60%, reaching 2.2 million new cases and 1.1 million deaths. In 2020, CRC accounted for 1.93 million new cases and 940,000 deaths, with the highest prevalence in New Zealand, Australia, and Europe, while lower rates were observed in Southern Asia and Africa. In Pakistan, CRC is the second most common cancer, accounting for 4.8% of all diagnoses. The risk factors include family history, smoking, genetic syndromes, and diet. Screening is recommended from the age of 45. Advances in immunotherapy, chemoradiotherapy, and targeted therapies have improved survival rates. This five-year study analyzed CRC cases at a Pakistani hospital to identify associations between various clinical and demographic factors and mortality.MethodsThis retrospective study, conducted at the Department of Surgery at Jinnah Post Medical Graduate Centre, Karachi, included 121 confirmed CRC patients from July 2022 to August 2024. Data from electronic medical records included diagnostic procedures and treatment histories. Tumor location and staging were determined according to the TNM staging system. Statistical analysis identified trends in tumour location, disease stage, and demographics.ResultsAmong the 121 patients with CRC, the majority were middle-aged (39.7%) and male (62%). The common symptoms included abdominal pain (65.3%) and constipation (43.8%). Most patients were in Duke stage C (42.1%), with metastasis in 7.2% of cases. Open surgery was performed in 71.9% of patients. Significant associations were found between vomiting, abdominal distention, fever, and mortality, as well as between cancer type and surgical method.ConclusionCRC is increasingly common in middle-aged individuals, and early onset CRC is increasing in Pakistan. Targeted screening and personalized treatment are crucial, and further research is needed to address the increasing incidence, especially in younger populations.

巴基斯坦三级医院结直肠癌患者的人口统计学关联和生存结果分析一项回顾性横断面研究。
结直肠癌(CRC)是全球第三大常见癌症,在工业化国家发病率更高。到2030年,结直肠癌病例数可能增加60%,达到220万新病例和110万死亡病例。2020年,结直肠癌新增病例193万例,死亡94万例,其中新西兰、澳大利亚和欧洲的患病率最高,南亚和非洲的患病率较低。在巴基斯坦,结直肠癌是第二大常见癌症,占所有诊断的4.8%。危险因素包括家族史、吸烟、遗传综合征和饮食。建议从45岁开始进行筛查。免疫治疗、放化疗和靶向治疗的进步提高了生存率。这项为期五年的研究分析了巴基斯坦一家医院的结直肠癌病例,以确定各种临床和人口因素与死亡率之间的关系。方法回顾性研究在卡拉奇真纳医学研究生中心外科进行,纳入了2022年7月至2024年8月121例确诊的结直肠癌患者。来自电子医疗记录的数据包括诊断程序和治疗历史。根据TNM分期系统确定肿瘤的位置和分期。统计分析确定了肿瘤位置、疾病分期和人口统计学的趋势。结果121例结直肠癌患者中,以中年(39.7%)和男性(62%)居多。常见症状为腹痛(65.3%)和便秘(43.8%)。大多数患者为Duke C期(42.1%),7.2%的病例发生转移。71.9%的患者行开放手术。研究发现,呕吐、腹胀、发烧和死亡率之间,以及癌症类型和手术方式之间存在显著关联。结论结直肠癌在中年人中越来越常见,早发性结直肠癌在巴基斯坦呈上升趋势。有针对性的筛查和个性化治疗至关重要,需要进一步研究以解决发病率上升的问题,特别是在年轻人群中。
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来源期刊
Cancer Control
Cancer Control ONCOLOGY-
CiteScore
3.80
自引率
0.00%
发文量
148
审稿时长
>12 weeks
期刊介绍: Cancer Control is a JCR-ranked, peer-reviewed open access journal whose mission is to advance the prevention, detection, diagnosis, treatment, and palliative care of cancer by enabling researchers, doctors, policymakers, and other healthcare professionals to freely share research along the cancer control continuum. Our vision is a world where gold-standard cancer care is the norm, not the exception.
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