Positive association between anti-Helicobacter pylori IgG antibody titers and atrophic gastritis in a Latvian cohort.

IF 5.1 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastric Cancer Pub Date : 2025-09-01 Epub Date: 2025-06-16 DOI:10.1007/s10120-025-01629-3

Joo Hyun Lim, Inese Poļaka, Danute Ražuka-Ebela, Inga Bogdanova, Sergei Parshutin, Mārcis Leja, Jin Young Park

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引用次数: 0

Abstract

Background: Although H. pylori is the most important risk factor for gastric cancer, the role of anti-H. pylori antibody titers in gastric carcinogenesis has not been investigated outside Asia. We aimed to analyze the relationship between H. pylori antibody titers and the risk of gastric precancerous lesions in a Caucasian population.

Methods: We analyzed the GISTAR pilot study data on participants from Latvia with available anti-H. pylori IgG antibody serology and histopathological information. Participants were classified into four groups according to antibody titer: low-negative (LN), high-negative (HN), low-positive (LP), and high-positive (HP). Odds ratios (ORs) for atrophic gastritis among the 4 groups were compared using logistic regression.

Results: Among a total of 1725 individuals, 970 with available histopathological information were included. A total of 738 individuals (76.1%) had histologically diagnosed atrophic gastritis. Risk of histological atrophic gastritis for each group compared to LN was as follows: HN (OR, 1.52; 95% confidence interval (CI) 0.85-2.72), LP (OR 2.04; 95% CI 1.25-3.32), and HP (OR, 2.47; 95% CI 1.50-4.07). Antibody titer as a continuous variable showed a positive relationship with histological atrophic gastritis (OR 1.09 per 10 EIU; 95% CI 1.04-1.14). The positive relationship was clearer among those aged ≥ 50 years.

Conclusions: Anti-H. pylori antibody titer was positively related to the risk of atrophic gastritis in a middle-aged Caucasian population, suggesting its potential complementary role in gastric cancer risk stratification in a European setting where upper endoscopic examination is less routinely available.

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在拉脱维亚队列中，抗幽门螺杆菌IgG抗体滴度与萎缩性胃炎呈正相关。

背景：虽然幽门螺杆菌是胃癌最重要的危险因素，但抗幽门螺杆菌的作用并不明显。幽门螺杆菌抗体滴度在胃癌发生中的作用尚未在亚洲以外地区进行研究。我们的目的是分析高加索人群中幽门螺杆菌抗体滴度与胃癌前病变风险之间的关系。方法：我们分析了拉脱维亚可用抗h抗体参与者的GISTAR试点研究数据。幽门螺杆菌IgG抗体血清学和组织病理学信息。根据抗体滴度将参与者分为四组：低阴性（LN）、高阴性（HN）、低阳性（LP）和高阳性（HP）。采用logistic回归比较4组间萎缩性胃炎的优势比（ORs）。结果：在1725个个体中，970个具有可用的组织病理学信息。738人（76.1%）组织学诊断为萎缩性胃炎。与LN相比，各组发生组织学萎缩性胃炎的风险如下：HN (OR, 1.52；95%置信区间（CI） 0.85-2.72), LP (OR 2.04；95% CI 1.25-3.32), HP (OR, 2.47；95% ci 1.50-4.07)。抗体滴度作为一个连续变量显示与组织学萎缩性胃炎呈正相关(OR 1.09 / 10 EIU；95% ci 1.04-1.14)。在年龄≥50岁的人群中，正相关关系更为明显。结论:Anti-H。在中年高加索人群中，幽门螺杆菌抗体滴度与萎缩性胃炎的风险正相关，这表明在上腔镜检查不太常见的欧洲环境中，幽门螺杆菌抗体滴度在胃癌风险分层中的潜在补充作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastric Cancer 医学-胃肠肝病学

CiteScore

14.70

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.