The role of cell-cell communication in renal damage and the therapeutic targeting of diabetic kidney disease.

IF 4.3 3区医学 Q1 UROLOGY & NEPHROLOGY

American Journal of Nephrology Pub Date : 2025-06-13 DOI:10.1159/000546739

Linxiao Lv, Wen Zheng, Mingyang Hu, Gladys Lai Ying Cheing, Zhangsuo Liu, Sijie Zhou, Alex Kwok Kuen Cheung

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引用次数: 0

Abstract

Background: Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes, and the increasing number of patients with this condition imposes a great economic burden globally. The rapid development of biotechnology has revealed more in-depth pathogenic mechanisms related to the occurrence of DKD. Lots of studies have provided evidence that communication between various cell types, including podocytes, mesangial cells, glomerular endothelial cells, and renal tubular epithelial cells, plays an irreplaceable role in the development of DKD. Stem cells have the unique advantages of establishing adaptive communication with renal cells to alleviate the damage in DKD. In addition, some drugs can also affect cell communication in DKD.

Summary: This review presents a review of recent progress on renal cellular crosstalk in the pathogenesis of DKD, and the findings of the review may shed light on the development of a novel therapeutic approach from the perspective of cellular communication.

Key message: Cellular communication in DKD not only reveals the new pathogenic mechanisms, but also provides potential therapeutic targets.

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细胞间通讯在肾损害中的作用及糖尿病肾病的治疗靶向。

背景：糖尿病肾病（DKD）是糖尿病常见的慢性微血管并发症，患者数量的增加给全球带来了巨大的经济负担。生物技术的快速发展揭示了与DKD发生有关的更深入的致病机制。大量研究表明，足细胞、系膜细胞、肾小球内皮细胞、肾小管上皮细胞等不同类型细胞之间的交流在DKD的发生发展中具有不可替代的作用。干细胞具有与肾细胞建立适应性通讯以减轻DKD损伤的独特优势。此外，一些药物也可以影响DKD中的细胞通讯。摘要：本文就肾细胞串扰在DKD发病机制中的研究进展进行综述，以期从细胞通讯的角度探索新的治疗方法。关键信息：DKD的细胞通讯不仅揭示了新的发病机制，而且提供了潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Nephrology 医学-泌尿学与肾脏学

CiteScore

7.50

自引率

2.40%

发文量

审稿时长

4-8 weeks

期刊介绍： The ''American Journal of Nephrology'' is a peer-reviewed journal that focuses on timely topics in both basic science and clinical research. Papers are divided into several sections, including: