{"title":"Paraspeckle Component 1: a multifunctional RNA binding protein.","authors":"Minyan Hao, Chandra Sugiarto Wijaya, Linyao Lu, Xian Wang, Jia Zhou","doi":"10.62347/RIWH3000","DOIUrl":null,"url":null,"abstract":"<p><p>Paraspeckle Component 1 (PSPC1), a Drosophila behavior/human splicing (DBHS) protein family member, represents a pivotal component within paraspeckles. It exerts indispensable functions across a wide array of biological processes, encompassing gene expression, the DNA damage response, the regulation of circadian rhythms, spermatogenesis, cell fate determination, and cancer metastasis. Notably, PSPC1 exhibits overexpression in several types of cancer, including hepatocellular carcinoma, lung cancer, and breast cancer, where it actively contributes to tumorigenesis. This overexpression phenomenon implies that PSPC1 holds the potential to serve as both a biomarker and a therapeutic target for these malignancies. Consequently, a substantial amount of research has been conducted to explore its structure, functions, and role in cancer development and progression. This review article aims to comprehensively summarize the current findings regarding PSPC1.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 5","pages":"2338-2352"},"PeriodicalIF":3.6000,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163449/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of cancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/RIWH3000","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Paraspeckle Component 1 (PSPC1), a Drosophila behavior/human splicing (DBHS) protein family member, represents a pivotal component within paraspeckles. It exerts indispensable functions across a wide array of biological processes, encompassing gene expression, the DNA damage response, the regulation of circadian rhythms, spermatogenesis, cell fate determination, and cancer metastasis. Notably, PSPC1 exhibits overexpression in several types of cancer, including hepatocellular carcinoma, lung cancer, and breast cancer, where it actively contributes to tumorigenesis. This overexpression phenomenon implies that PSPC1 holds the potential to serve as both a biomarker and a therapeutic target for these malignancies. Consequently, a substantial amount of research has been conducted to explore its structure, functions, and role in cancer development and progression. This review article aims to comprehensively summarize the current findings regarding PSPC1.
期刊介绍：
The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.
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