Advancing FIRES Treatment: The Potential of Intrathecal Dexamethasone

Annals of the Child Neurology Society Pub Date : 2025-05-11 DOI:10.1002/cns3.70008

Carol Park, Douglas R. Nordli III, Mohamed Taha, Henry David, Shawn Kacker, Tareq Kass-Hout, Sonam Thind, Aurelie Hanin, Sana Said, Hiba A. Haider, Douglas R. Nordli Jr.

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Abstract

Background

Febrile infection-related epilepsy syndrome (FIRES) is a rare, devastating epilepsy syndrome characterized by refractory status epilepticus following a febrile illness.

Patient Description

We describe a 12-year-old girl with FIRES who exhibited a remarkable clinical and electrographic response to intrathecal dexamethasone (IT-DEX) after failing multiple antiseizure and immunomodulatory therapies. Despite persistent neuroinflammation, IT-DEX led to rapid seizure control and significant neurological recovery.

Conclusion

This report supports IT-DEX as a promising intervention in FIRES and underscores the need for further research into its mechanisms and long-term efficacy.

Abstract Image

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推进火灾治疗：鞘内地塞米松的潜力

背景发热性感染相关癫痫综合征（FIRES）是一种罕见的破坏性癫痫综合征，其特征是发热性疾病后的难治性癫痫持续状态。我们描述了一名患有FIRES的12岁女孩，在多次抗癫痫和免疫调节治疗失败后，她对鞘内地塞米松（IT-DEX）表现出显着的临床和电反应。尽管持续的神经炎症，IT-DEX导致快速控制癫痫发作和显著的神经恢复。结论本报告支持IT-DEX作为一种有前景的干预措施，并强调需要进一步研究其机制和长期疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of the Child Neurology Society

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