The low-flow mask oxygen could be a more effective, comfortable, and easy-to-follow treatment for psychogenic hyperventilation syndrome: A double-blind, randomized controlled trial

IF 1.8 4区医学 Q2 NURSING

International Emergency Nursing Pub Date : 2025-06-17 DOI:10.1016/j.ienj.2025.101636

Linhe Yang , Dongmei Yuan , Zhenyu Luo , Yunying Li , Xiuli Zhu

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引用次数: 0

Abstract

Objectives

To compare the effect of low-flow mask oxygenation (LFMO) with breathing training (BT) for psychogenic hyperventilation syndrome (PHVS), providing more options and evidence for clinical treatment.

Methods

The randomized double-blinded controlled trial was prospectively registered in the Chinese Clinical Trial Registry on 1 June 2023 under the defined number (ChiCTR2300072044) and subsequently approved by the Ethics Committee (REDACT) (GYZXLL2023070). From 10 May 2024 to 23 November 2024, participants with PHVS were recruited and blindly randomized into the LFMO group and the BT group, then the LFMO group inhaled 3L/minute oxygen with the oxygen mask and breathed freely, while the BT group performed the breath training led by researchers face-to-face. The recovery length from PHVS, the Nijmegen Questionnaire score at fifteen minutes since the intervention, the Nijmegen Questionnaire score at the end of the intervention, and the comfort/tolerance score (participant rating via NRS) were collected as the primary outcome. The secondary outcome was measured by the mean breath rate during the recovery (Calculated by dividing the total number of breaths during the intervention by time) and laboratory results, including the PH, lactate, K+, Ca2+, PO₂, and PCo₂.

Results

Forty-five participants (all Asian) completed the study and were included in the analysis (21 for the LFMO group and 24 for the BT group), mainly female (75 %, n = 33). All demographic characteristics between the two groups are within the reasonable range and show no significant difference. However, significant differences were measured among the outcomes, including the oxygen index (480.22 ± 29.64, 311.01 ± 15.45, p < 0.001), Mean breath rate during recovery (19.17 ± 1.74, 28.24 ± 2.53, p < 0.001), and the LFMO group showed significant advantages in both the length of recovery (22.94 ± 2.81, p < 0.001) and comfort/tolerance (5.86 ± 1.24, p < 0.001).

Conclusion

Compared to breath training therapy, the low-flow mask oxygenation could be a more effective, comfortable, and easy-to-follow treatment for PHVS.

查看原文本刊更多论文

低流量面罩氧气可能是一种更有效、更舒适、更易于遵循的治疗心因性过度通气综合征的方法：一项双盲、随机对照试验

目的比较低流量面罩氧合（LFMO）与呼吸训练（BT）治疗心因性过度通气综合征（PHVS）的效果，为临床治疗提供更多选择和依据。方法该随机双盲对照试验于2023年6月1日在中国临床试验注册中心前瞻性注册，编号为ChiCTR2300072044，随后经伦理委员会（REDACT）批准（GYZXLL2023070）。2024年5月10日至11月23日，招募PHVS患者，随机随机分为LFMO组和BT组，LFMO组通过氧气面罩吸入3L/min氧气自由呼吸，BT组在研究人员的面对面指导下进行呼吸训练。PHVS的恢复时间、干预后15分钟奈美亨问卷评分、干预结束时奈美亨问卷评分和舒适/耐受评分（通过NRS进行的参与者评分）作为主要结果。次要结局通过恢复期间的平均呼吸率（通过干预期间的总呼吸次数除以时间计算）和实验室结果测量，包括PH、乳酸、K+、Ca2+、PO2和PCo2。结果45名参与者（均为亚洲人）完成研究并纳入分析（LFMO组21名，BT组24名），主要为女性（75%,n = 33）。两组人口统计学特征均在合理范围内，无显著差异。但两组间氧指数(480.22±29.64,311.01±15.45,p <；0.001)，恢复期间平均呼吸频率(19.17±1.74,28.24±2.53,p <；0.001)， LFMO组在恢复时间(22.94±2.81,p <；0.001)和舒适/公差(5.86±1.24,p <；0.001)。结论与呼吸训练治疗相比，低流量面罩氧合治疗PHVS更有效、舒适、易于随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Emergency Nursing NURSING-

CiteScore

3.20

自引率

11.10%

发文量

期刊介绍： International Emergency Nursing is a peer-reviewed journal devoted to nurses and other professionals involved in emergency care. It aims to promote excellence through dissemination of high quality research findings, specialist knowledge and discussion of professional issues that reflect the diversity of this field. With an international readership and authorship, it provides a platform for practitioners worldwide to communicate and enhance the evidence-base of emergency care. The journal publishes a broad range of papers, from personal reflection to primary research findings, created by first-time through to reputable authors from a number of disciplines. It brings together research from practice, education, theory, and operational management, relevant to all levels of staff working in emergency care settings worldwide.