Health-related reference intervals for heavy metals in non-exposed young adults.

IF 3.8 2区医学 Q1 MEDICAL LABORATORY TECHNOLOGY

Clinical chemistry and laboratory medicine Pub Date : 2025-06-16 DOI:10.1515/cclm-2025-0076

Chiara Di Resta, Francesco Paleari, Assunta Naclerio, Floriana Iannace, Roberto Leone, Ivan Shashkin, Marco Fumagalli, Chiara Sacco, Lucia Bellocchi, Massimo Locatelli, Giuseppe Banfi, Paola M V Rancoita, Rossella Tomaiuolo

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引用次数: 0

Abstract

Objectives: Heavy Metals (HMs) concentrations vary with living environments, diet, and personal habits. This study aims to establish health-related reference intervals (RIs) for selected HMs in healthy, non-occupationally exposed young adults living in an urban environment.

Methods: The Uni4Me study enrolled 154 healthy university volunteers (median age: 23 years) to assess the concentrations of seven heavy metals (lead, nickel, cadmium, zinc, chromium, cobalt, and mercury) using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-EOS). CLSI guidelines were followed to estimate the 2.5th and 97.5th percentiles as RIs.

Results: Most metals were detected at low concentrations. Zinc showed consistent physiological levels in all participants. Mercury and chromium were the most frequently detected, indicating potential environmental or dietary exposure.

Conclusions: This study defines baseline values for HMs in an urban, healthy, young adult population. These results may support future biomonitoring efforts and public health initiatives targeting subclinical exposure in non-occupationally exposed populations.

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未接触重金属的年轻人健康相关参考区间。

目的：重金属（HMs）浓度随生活环境、饮食和个人习惯而变化。本研究的目的是建立健康相关参考区间（RIs），选择健康的，非职业暴露的年轻成年人生活在城市环境中。方法：Uni4Me研究招募了154名健康的大学志愿者（中位年龄：23岁），使用电感耦合等离子体质谱法（ICP-MS）和电感耦合等离子光学发射光谱法（ICP-EOS）评估七种重金属（铅、镍、镉、锌、铬、钴和汞）的浓度。遵循CLSI指南估计第2.5和97.5%为RIs。结果：大多数金属在低浓度下检出。锌在所有参与者中显示出一致的生理水平。汞和铬是最常检测到的，表明潜在的环境或饮食暴露。结论：本研究确定了城市健康青年人群的HMs基线值。这些结果可能支持未来针对非职业暴露人群亚临床暴露的生物监测工作和公共卫生倡议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical chemistry and laboratory medicine 医学-医学实验技术

CiteScore

11.30

自引率

16.20%

发文量

306

审稿时长

3 months

期刊介绍： Clinical Chemistry and Laboratory Medicine (CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor over 3. CCLM is issued monthly, and it is published in print and electronically. CCLM is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and publishes regularly EFLM recommendations and news. CCLM is the official journal of the National Societies from Austria (ÖGLMKC); Belgium (RBSLM); Germany (DGKL); Hungary (MLDT); Ireland (ACBI); Italy (SIBioC); Portugal (SPML); and Slovenia (SZKK); and it is affiliated to AACB (Australia) and SFBC (France). Topics: - clinical biochemistry - clinical genomics and molecular biology - clinical haematology and coagulation - clinical immunology and autoimmunity - clinical microbiology - drug monitoring and analysis - evaluation of diagnostic biomarkers - disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes) - new reagents, instrumentation and technologies - new methodologies - reference materials and methods - reference values and decision limits - quality and safety in laboratory medicine - translational laboratory medicine - clinical metrology Follow @cclm_degruyter on Twitter!