The Link between Alcohol Consumption and Kidney Injury.

IF 4.7 2区 医学 Q1 PATHOLOGY
Burhan Yokus, Luca Maccioni, Lihong Fu, György Haskó, Laura E Nagy, Bin Gao, Pal Pacher
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引用次数: 0

Abstract

Alcohol consumption contributes to systemic organ dysfunction, but its direct effect on kidney health is unclear. Epidemiologic studies have shown inconsistent findings due to a reliance on conventional markers, such as serum creatinine and blood urea nitrogen, which are insensitive to early chronic kidney disease and influenced by factors such as muscle mass, diet, and hydration status. Experimental studies have indicated that alcohol may directly exacerbate renal damage through mitochondrial dysfunction, oxidative stress, and inflammation. Furthermore, indirect effects from alcohol-induced altered intestinal permeability and microbiome, liver injury, microcirculatory/cardiac dysfunction and muscle damage may also facilitate kidney damage. Notably, alcohol-related liver disease can lead to hepatorenal syndrome, a severe type of kidney dysfunction driven by circulatory disturbances and systemic inflammation. This overview explores the adverse effects of alcohol misuse on kidney health and disease, emphasizing the need for comprehensive epidemiologic studies with more sensitive kidney injury biomarkers. It also highlights the importance of using clinically relevant preclinical models to clarify the underlying mechanisms of alcohol-related kidney injury and to enhance the understanding of its long-term clinical consequences.

饮酒与肾损伤之间的联系
饮酒会导致全身器官功能障碍,但其对肾脏健康的直接影响尚不清楚。流行病学研究显示,由于依赖于血清肌酐(sCr)和血尿素氮(BUN)等传统标志物,结果不一致,这些标志物对早期慢性肾脏疾病(CKD)不敏感,并受肌肉质量、饮食和水合状态等因素的影响。实验研究表明,酒精可通过线粒体功能障碍、氧化应激和炎症直接加重肾损伤。此外,酒精诱导的肠通透性和微生物组改变、肝损伤、微循环/心功能障碍和肌肉损伤的间接影响也可能促进肾脏损伤。值得注意的是,酒精相关的肝脏疾病可导致肝肾综合征,这是一种由循环障碍和全身性炎症引起的严重肾功能障碍。这篇综述探讨了酒精滥用对肾脏健康和疾病的不良影响,强调需要更敏感的肾损伤生物标志物进行全面的流行病学研究。它还强调了使用临床相关的临床前模型来阐明酒精相关肾损伤的潜在机制并增强我们对其长期临床后果的理解的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.40
自引率
0.00%
发文量
178
审稿时长
30 days
期刊介绍: The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.
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