Associations Between Dietary Carotenoid Intake and Plasma Carotenoid Concentrations and Skin Yellowness, a Validation Study

IF 2.9 3区医学 Q3 NUTRITION & DIETETICS

Journal of Human Nutrition and Dietetics Pub Date : 2025-06-16 DOI:10.1111/jhn.70075

Erin D. Clarke, Mitch J. Duncan, Tracy Burrows, María Gómez-Martín, Katherine Brain, Jordan Stanford, Jessica J. A. Ferguson, Lisa Wood, Clare E. Collins

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引用次数: 0

Abstract

Background

Carotenoids are pigments abundant in fruits and vegetables and can be measured in plasma and skin. This study aimed to evaluate associations between carotenoid intake, assessed by self-reported usual diet against plasma carotenoid and skin yellowness concentrations in Australian adults (n = 50, aged 39.3 ± 15.4 years, 68% female).

Methods

Dietary carotenoid intakes were quantified using the Australian Eating Survey (AES) food frequency questionnaire (total, α- and β-carotene, lycopene, β-cryptoxanthin, and lutein/zeaxanthin). Plasma concentrations of these carotenoids were measured using high-performance liquid chromatography, while skin yellowness was measured using skin reflectance spectroscopy as a proxy for skin carotenoids. Associations between AES carotenoids, plasma carotenoids and total skin yellowness were analysed using linear regressions.

Results

AES-derived carotenoid intakes were positively associated with skin yellowness for all dietary carotenoids (β range 0.25–0.46, p < 0.05) and total dietary carotenoids (β = 0.35 [95% CI 0.07, 0.63], p < 0.05), except lycopene. Similarly, each individual plasma carotenoid was significantly positively associated with their respective individual dietary carotenoids (β range 0.42–0.53, p < 0.05) and total dietary carotenoids (β = 0.38 [95% CI 0.04, 0.73], p < 0.05), except for lycopene. Significant positive associations were identified between skin yellowness and total (β = 0.36 [0.20, 0.52], p < 0.001) and individual plasma carotenoids (β range 0.30–0.37, p < 0.01), excluding α-carotene and lycopene.

Conclusion

Dietary carotenoid intakes were significantly associated with plasma carotenoid concentrations and skin yellowness values. Results support use of all three methods for assessment of carotenoid intake, with the exception of lycopene. Future studies should consider cost, accessibility of assessment methods and participant burden when selecting dietary assessment methods.

Trial Registration

The original study was registered with Australian New Zealand Clinical Trials Registry (ANZCTR-12619001415190).

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膳食类胡萝卜素摄入量、血浆类胡萝卜素浓度和皮肤黄度之间的关系：一项验证性研究

类胡萝卜素是水果和蔬菜中富含的色素，可以在血浆和皮肤中检测到。本研究旨在评估类胡萝卜素摄入量与血浆类胡萝卜素和皮肤黄度浓度之间的关系，通过自我报告的日常饮食来评估（n = 50，年龄39.3±15.4岁，68%为女性）。方法采用澳大利亚饮食调查（AES）食物频率问卷（总摄入量、α-和β-胡萝卜素、番茄红素、β-隐黄质和叶黄素/玉米黄质）对日粮类胡萝卜素摄入量进行量化。这些类胡萝卜素的血浆浓度用高效液相色谱法测定，而皮肤黄度用皮肤反射光谱法作为皮肤类胡萝卜素的代理来测定。用线性回归分析AES类胡萝卜素、血浆类胡萝卜素和皮肤总黄度之间的关系。结果aes衍生类胡萝卜素的摄入量与除番茄红素外的所有类胡萝卜素（β范围为0.25-0.46,p < 0.05）和总类胡萝卜素（β = 0.35 [95% CI 0.07, 0.63], p < 0.05）的皮肤黄度呈正相关。同样，除番茄红素外，每种血浆类胡萝卜素与各自的饲料类胡萝卜素（β = 0.42-0.53, p < 0.05）和总饲料类胡萝卜素（β = 0.38 [95% CI 0.04, 0.73], p < 0.05）呈显著正相关。皮肤黄度与总类胡萝卜素（β = 0.36 [0.20, 0.52], p < 0.001）和血浆类胡萝卜素（β范围0.30-0.37,p < 0.01）之间存在显著正相关，不包括α-胡萝卜素和番茄红素。结论饲粮类胡萝卜素摄入量与血浆类胡萝卜素浓度和皮肤黄度值显著相关。结果支持使用所有三种方法来评估类胡萝卜素的摄入量，但番茄红素除外。未来的研究在选择膳食评估方法时应考虑成本、评估方法的可及性和参与者负担。原始研究已在澳大利亚新西兰临床试验登记处注册（anztr -12619001415190）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Human Nutrition and Dietetics 医学-营养学

CiteScore

5.30

自引率

15.20%

发文量

133

审稿时长

6-12 weeks

期刊介绍： Journal of Human Nutrition and Dietetics is an international peer-reviewed journal publishing papers in applied nutrition and dietetics. Papers are therefore welcomed on: - Clinical nutrition and the practice of therapeutic dietetics - Clinical and professional guidelines - Public health nutrition and nutritional epidemiology - Dietary surveys and dietary assessment methodology - Health promotion and intervention studies and their effectiveness - Obesity, weight control and body composition - Research on psychological determinants of healthy and unhealthy eating behaviour. Focus can for example be on attitudes, brain correlates of food reward processing, social influences, impulsivity, cognitive control, cognitive processes, dieting, psychological treatments. - Appetite, Food intake and nutritional status - Nutrigenomics and molecular nutrition - The journal does not publish animal research The journal is published in an online-only format. No printed issue of this title will be produced but authors will still be able to order offprints of their own articles.