Effects of lifestyle modification counselling on weight and body composition among adults with overweight or obesity on antiretroviral therapy: a randomized controlled trial

Obesity Pillars Pub Date : 2025-06-06 DOI:10.1016/j.obpill.2025.100184

Agete Tadewos Hirigo , Moges Derbe , Daniel Yilma , Ayalew Astatkie , Zelalem Debebe

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Abstract

Background

we aimed to evaluate the impact of lifestyle modification counselling on weight and body composition among adults with overweight or obesity receiving antiretroviral treatment (ART).

Methods

This randomized, open-label, controlled trial enrolled 126 adults aged 18–65 years, living with human immunodeficiency virus (HIV) and classified as overweight or obese. Of these, 116 participants (63 in the control group and 53 in the intervention group) completed the six-month follow-up. Weight and body composition outcomes were analyzed among those who completed the study, with comparisons made between baseline and post-intervention measurements. The effect of lifestyle modification counselling on weight and body composition was evaluated through linear mixed effects model and multiple linear regression analysis.

Results

Over the six-month trial, participants who received lifestyle modification counselling showed significantly greater reductions in body weight (Δ = −1.4 kg, p = 0.002), visceral fat (Δ = −0.53, p = 0.006), fat mass (Δ = −2.16 kg, p < 0.001), and body fat percentage (Δ = −2.02 %, p < 0.001) compared to the control group. The intervention group experienced greater increases in fat-free mass (Δ = +0.673 kg, p = 0.068) and percentage skeletal muscle (Δ = +1.27 %, p < 0.001) compared to the control group. Additionally, lifestyle modification counselling significantly contributed to achieving at least a 3 % weight loss from baseline (β = 0.158, p = 0.048).

Conclusion

Lifestyle modification counselling resulted in promising and favorable changes in weight and body composition. Therefore, offering routine structured counselling interventions within ART clinics for individuals with overweight or obesity may help reduce obesity-related health risks and improve clinical outcomes (Thai Clinical Trials Registry TCTR20240905007).

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生活方式改变咨询对接受抗逆转录病毒治疗的超重或肥胖成人体重和身体成分的影响：一项随机对照试验

背景：我们旨在评估生活方式改变咨询对接受抗逆转录病毒治疗（ART）的超重或肥胖成年人体重和身体组成的影响。方法：这项随机、开放标签、对照试验招募了126名年龄在18-65岁、携带人类免疫缺陷病毒（HIV）、超重或肥胖的成年人。其中，116名参与者（对照组63名，干预组53名）完成了为期6个月的随访。对完成研究的人的体重和身体组成结果进行了分析，并对基线和干预后的测量结果进行了比较。通过线性混合效应模型和多元线性回归分析，评价生活方式改变咨询对体重和体成分的影响。结果在为期6个月的试验中，接受生活方式改变咨询的参与者在体重（Δ = - 1.4 kg, p = 0.002）、内脏脂肪（Δ = - 0.53, p = 0.006）、脂肪量(Δ = - 2.16 kg, p <；0.001)和体脂百分比(Δ=−2.02%,p & lt;0.001)，与对照组相比。干预组无脂质量（Δ = +0.673 kg, p = 0.068）和骨骼肌百分比(Δ = + 1.27%, p <；0.001)，与对照组相比。此外，生活方式改变咨询显著有助于实现至少3%的体重减轻（β = 0.158, p = 0.048）。结论生活方式改变咨询可使体重和身体成分发生有希望和有利的变化。因此，在抗逆转录病毒治疗诊所为超重或肥胖个体提供常规的结构化咨询干预可能有助于减少与肥胖相关的健康风险并改善临床结果（泰国临床试验登记处TCTR20240905007）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Obesity Pillars

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