1865-LB: Association between Bariatric Surgery and Albuminuria in Adolescents with and at Risk of Diabetes

IF 6.2 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2025-06-13 DOI:10.2337/db25-1865-lb

KANCHANA PERERA, JOHN BAKER, KAREN A. PICKERING, PATRICIA J. HARRY, BRANDON J. ORR-WALKER, DAVID SIMMONS

{"title":"1865-LB: Association between Bariatric Surgery and Albuminuria in Adolescents with and at Risk of Diabetes","authors":"KANCHANA PERERA, JOHN BAKER, KAREN A. PICKERING, PATRICIA J. HARRY, BRANDON J. ORR-WALKER, DAVID SIMMONS","doi":"10.2337/db25-1865-lb","DOIUrl":null,"url":null,"abstract":"Introduction and Objective: Obesity is a major health issue worldwide, with a higher rate of severe obesity among adolescents in South Auckland compared to other parts of New Zealand. While bariatric surgery is an effective treatment for severely obese adults, there is limited evidence on its effectiveness for adolescents. This study will explore how intensive lifestyle changes, with or without bariatric surgery, affect Urine Albumin Creatinine Ratio (UACR), a measure of kidney function, in Māori and Pasifika adolescents. Methods: Adolescents (15-17 years old) with a BMI≥35 followed a 12-week weight loss program using a Very Low-Calorie Diet (VLCD) based on the Optifast program. After 12 weeks, eligible participants were offered bariatric surgery. Longitudinal mixed effects models were used to analyze how surgery, gender, weight change, and time affected UACR levels. Results: Out of 21 participants (12F, 9M), 6 (4F, 2M) had bariatric surgery. The analysis showed no overall effect of time or surgery alone, but there was a significant interaction effect (p&lt;0.001). Participants who had bariatric surgery showed a decrease in log(UACR), while those who didn't have surgery showed either a stable or increasing trend. Conclusion: Bariatric surgery significantly modifies the time effect on log(UACR), leading to a greater reduction in UACR levels over time compared to non-surgery participants, potentially predicting less significant or delayed nephropathy into the future. Disclosure K. Perera: None. J. Baker: None. K.A. Pickering: None. P.J. Harry: None. B.J. Orr-Walker: None. D. Simmons: Research Support; Novo Nordisk, AMSL. Other Relationship; Abbott, Abbott, Boehringer-Ingelheim. Speaker's Bureau; Ascensia Diabetes Care.","PeriodicalId":11376,"journal":{"name":"Diabetes","volume":"11 1","pages":""},"PeriodicalIF":6.2000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2337/db25-1865-lb","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction and Objective: Obesity is a major health issue worldwide, with a higher rate of severe obesity among adolescents in South Auckland compared to other parts of New Zealand. While bariatric surgery is an effective treatment for severely obese adults, there is limited evidence on its effectiveness for adolescents. This study will explore how intensive lifestyle changes, with or without bariatric surgery, affect Urine Albumin Creatinine Ratio (UACR), a measure of kidney function, in Māori and Pasifika adolescents. Methods: Adolescents (15-17 years old) with a BMI≥35 followed a 12-week weight loss program using a Very Low-Calorie Diet (VLCD) based on the Optifast program. After 12 weeks, eligible participants were offered bariatric surgery. Longitudinal mixed effects models were used to analyze how surgery, gender, weight change, and time affected UACR levels. Results: Out of 21 participants (12F, 9M), 6 (4F, 2M) had bariatric surgery. The analysis showed no overall effect of time or surgery alone, but there was a significant interaction effect (p<0.001). Participants who had bariatric surgery showed a decrease in log(UACR), while those who didn't have surgery showed either a stable or increasing trend. Conclusion: Bariatric surgery significantly modifies the time effect on log(UACR), leading to a greater reduction in UACR levels over time compared to non-surgery participants, potentially predicting less significant or delayed nephropathy into the future. Disclosure K. Perera: None. J. Baker: None. K.A. Pickering: None. P.J. Harry: None. B.J. Orr-Walker: None. D. Simmons: Research Support; Novo Nordisk, AMSL. Other Relationship; Abbott, Abbott, Boehringer-Ingelheim. Speaker's Bureau; Ascensia Diabetes Care.

查看原文本刊更多论文

1865-LB：青少年糖尿病患者和糖尿病风险患者的减肥手术与蛋白尿之间的关系

简介和目的：肥胖是世界范围内的一个主要健康问题，与新西兰其他地区相比，南奥克兰青少年的严重肥胖率更高。虽然减肥手术对严重肥胖的成年人是一种有效的治疗方法，但对青少年的有效性证据有限。本研究将探讨在Māori和Pasifika青少年中，生活方式的剧烈改变，无论是否进行减肥手术，如何影响尿白蛋白肌酐比（UACR），一种肾功能指标。方法：BMI≥35的青少年（15-17岁）在Optifast项目的基础上，采用极低热量饮食（VLCD）进行为期12周的减肥计划。12周后，符合条件的参与者接受减肥手术。纵向混合效应模型用于分析手术、性别、体重变化和时间如何影响UACR水平。结果：在21名参与者（12F, 9M）中，6名（4F, 2M）进行了减肥手术。分析显示，时间或手术本身没有总体影响，但存在显著的相互作用（p<0.001）。接受减肥手术的参与者显示出log（UACR）的下降，而未接受手术的参与者则显示出稳定或增加的趋势。结论：减肥手术显著改变了时间效应（UACR），与非手术参与者相比，随着时间的推移，UACR水平下降幅度更大，可能预测未来不太明显或延迟的肾病。佩雷拉：没有。贝克：没有。K.A.皮克林：没有。哈利：没有。B.J. Orr-Walker：没有。D. Simmons：研究支持；诺和诺德，AMSL。其他关系;雅培，雅培，勃林格殷格翰。演讲者的局;Ascensia Diabetes Care。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.