1500-P: Global Trends in Mortality and Disability Adjusted Life Years (DALYs) of Type 1 Diabetes Mellitus in Adolescents and Young Adults (15–39y) from 1990 to 2021

IF 6.2 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2025-06-13 DOI:10.2337/db25-1500-p

MUHAMMAD USMAN HAIDER, HUSNAIN AHMAD, IFFAT A. MAGSI, MIAN ZAHID JAN KAKAKHEL, UMAR HAYAT, ISHTIAQ AHMAD

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引用次数: 0

Abstract

Introduction and Objective: Type 1 Diabetes Mellitus (T1DM) poses a substantial global health burden, particularly among adolescents and young adults. This study examines trends in Disability-Adjusted Life Years and mortality associated with T1DM from 1990 to 2021. Methods: Data on DALYs and mortality for individuals aged 15-39 years were collected from Global Burden of Disease study and analyzed using Joinpoint regression models. APC and AAPC were calculated to identify temporal trends. Statistical significance was determined using p-values (<0.05). Results: From 1990 to 2021, T1DM caused a combined 495562 deaths and 40819490 DALYs. DALYs exhibited a slight overall decline (AAPC: -0.0657, 95% CI: -0.098 to -0.028, p = 0.0016), with the most significant reduction from 2000 to 2012 (APC: -0.8420, 95% CI: -0.946 to -0.750, p = 0.0192). However, a slight increase was noted between 2012 and 2021 (APC: 0.2190, 95% CI: 0.091 to 0.375, p = 0.0128). Mortality rates declined more pronouncedly (AAPC: -0.3514, 95% CI: -0.387 to -0.3088, p < 0.000001), with the decrease during 2000-2011 (APC: -1.4747, 95% CI: -1.841 to -1.400, p < 0.000001). Slight increases occurred during 2014-2017 (APC: 0.8121, 95% CI: 0.340 to 1.134, p = 0.0044). Conclusion: While the global burden of T1DM has generally declined, periods of increasing trends highlight the need for sustained public health efforts and research into contributing factors. Disclosure M. Haider: None. H. Ahmad: None. I.A. Magsi: None. M. Kakakhel: None. U. Hayat: None. I. Ahmad: None.

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1500-P: 1990年至2021年青少年和年轻人（15 - 39岁）1型糖尿病死亡率和残疾调整生命年（DALYs）的全球趋势

简介和目的：1型糖尿病（T1DM）造成了巨大的全球健康负担，特别是在青少年和年轻人中。本研究调查了1990年至2021年与T1DM相关的残疾调整生命年和死亡率的趋势。方法：从全球疾病负担研究中收集15-39岁个体的DALYs和死亡率数据，并使用Joinpoint回归模型进行分析。计算APC和AAPC以确定时间趋势。采用p值（<0.05）确定统计学意义。结果：从1990年到2021年，T1DM共造成495562例死亡和40819490例DALYs。DALYs总体上略有下降（AAPC: -0.0657, 95% CI: -0.098 ~ -0.028, p = 0.0016），其中2000 - 2012年下降最为显著（APC: -0.8420, 95% CI: -0.946 ~ -0.750, p = 0.0192）。然而，在2012年至2021年间略有增加（APC: 0.2190, 95% CI: 0.091至0.375,p = 0.0128）。死亡率下降更为明显(AAPC: -0.3514, 95% CI: -0.387至-0.3088,p <；0.000001)， 2000-2011年间呈下降趋势(APC: -1.4747, 95% CI: -1.841 ~ -1.400, p <；0.000001)。2014-2017年略有增加（APC: 0.8121, 95% CI: 0.340 ~ 1.134, p = 0.0044）。结论：虽然T1DM的全球负担总体上有所下降，但有增加趋势的时期突出表明需要持续的公共卫生努力和对促成因素的研究。海德尔：没有。艾哈迈德：没有。马格西：没有。卡卡赫尔：没有。哈亚特：没有。艾哈迈德：没有。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.