Deprotonated 5-acetylmethyl-1,2,4-oxadiazoles as bidentate chelating ligands for the synthesis of palladium(II) and copper(II) complexes

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-06-14 DOI:10.1016/j.ica.2025.122817

Jacob U. Abulkhaev , Artem V. Semenov , Daniil M. Ivanov , Irina I. Fedorova , Eugene V. Ignatov , Ekaterina A. Radiush , Sergey V. Baykov , Nadezhda A. Bokach

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引用次数: 0

Abstract

Neutral bis-chelate complexes M(L)₂ (M = Pd(II); LH = 3-R-5-acetylmethyl-1,2,4-oxadiazole: R = Me 1a, Et 1b, Bn 1c, Ph 1d, 4-Tol 1e; M = Cu(II); LH = 3-R-5-acetylmethyl-1,2,4-oxadiazole: R = Me 2a, Et 2b, Bn 2c, Ph 2d, 4-Tol 2e) were synthesized in moderate to good yields (61–87%) by the reaction of the corresponding 5-acetylmethyl-1,2,4-oxadiazole with Na₂[PdCl₄] or CuCl₂·2H₂O in the presence of sodium tert-butoxide as a base. The complexes were characterized by IR (1a–e and 2a–e) and ¹H and ¹³C{¹H} NMR spectroscopy (1a–e), electrospray ionization high-resolution mass spectrometry (ESI-HRMS; 1a–e and 2a–e), and powder X-ray diffraction analysis (2a–e). Compounds 1a–e and 2a–e are also characterized by single-crystal X-ray diffraction data. Their coordination geometries and supramolecular organization differ significantly depending on the nature of the metal center and the substituent R.

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去质子化5-乙酰甲基-1,2,4-恶二唑作为双齿螯合配体用于钯（II）和铜（II）配合物的合成

中性双螯合物M(L)2 (M = Pd(II)；LH = 3-R-5-乙酰甲基-1,2,4-恶二唑：R = Me 1a, Et 1b, Bn 1c, Ph 1d, 4-Tol 1e；M = Cu(II)；LH = 3-R-5-乙酰甲基-1,2,4-恶二唑：R = Me 2a, Et 2b, Bn 2c, Ph 2d, 4-Tol 2e)在叔丁二氧化钠的存在下，由相应的5-乙酰甲基-1,2,4-恶二唑与Na2[PdCl4]或CuCl2·2H2O反应，以中高收率（61-87%）合成。通过IR （1a-e和2a-e）、1H和13C{1H} NMR （1a-e）、电喷雾电离高分辨率质谱(ESI-HRMS；（1a-e和2a-e），粉末x射线衍射分析（2a-e）。化合物1a-e和2a-e也通过单晶x射线衍射数据进行了表征。它们的配位几何形状和超分子组织根据金属中心和取代基R的性质有很大的不同。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.