Room-temperature nickel-catalyzed borylation/cyclization synthesis of benzoxaboroles and benzodiazaborines

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-06-13 DOI:10.1039/d5qo00728c

Xiaoning Yang, Shuyan Wu, Jiayi Wang, Yanqing Peng, Gonghua Song

引用次数: 0

Abstract

Benzoxaboroles and benzodiazaborines are pivotal in medicinal chemistry due to their unique biological activities and potential as therapeutic agents. Herein, we present a room-temperature, nickel-catalyzed borylation protocol for the efficient synthesis. Utilizing an inexpensive nickel catalyst system, this method provides a facile synthetic method for a wide range of target compounds. This cost-effective approach offers a sustainable alternative to traditional palladium-based methods, aligning with green chemistry principles by reducing energy input and enhancing reaction efficiency. In addition to expanding the range of boronic acid derivatives, the developed methodology holds significant promise for advancing applications in drug discovery.

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室温镍催化硼化/环化合成苯并恶硼和苯并二氮杂硼

苯并恶aboroles和苯并二氮杂aborines由于其独特的生物活性和作为治疗剂的潜力在药物化学中至关重要。在此，我们提出了一种室温，镍催化的硼化反应方案，用于高效合成。利用廉价的镍催化剂体系，该方法为广泛的目标化合物提供了一种简便的合成方法。这种具有成本效益的方法为传统的钯基方法提供了一种可持续的替代方案，通过减少能量输入和提高反应效率，与绿色化学原则保持一致。除了扩大硼酸衍生物的范围外，所开发的方法对于推进药物发现的应用具有重要的希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.