Anti-Breast Cancer Effects of Thymoquinone-Chemotherapeutic Combinations: A Systematic Review of the Latest In Vitro and In Vivo Studies.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Journal of clinical medicine research Pub Date : 2025-05-01 Epub Date: 2025-05-28 DOI:10.14740/jocmr6230
Nur Qodir, Legiran, Zen Hafy, Didit Pramuditho, Muhammad Baharul Iman, Fara Syafira, Raehan Satya Deanasa, Putri Mahirah Afladhanti
{"title":"Anti-Breast Cancer Effects of Thymoquinone-Chemotherapeutic Combinations: A Systematic Review of the Latest <i>In Vitro</i> and <i>In Vivo</i> Studies.","authors":"Nur Qodir, Legiran, Zen Hafy, Didit Pramuditho, Muhammad Baharul Iman, Fara Syafira, Raehan Satya Deanasa, Putri Mahirah Afladhanti","doi":"10.14740/jocmr6230","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is a leading malignancy among women globally, with chemotherapy as a cornerstone of treatment. However, the side effects and toxicity associated with chemotherapy necessitate the exploration of adjunctive therapies to improve efficacy and reduce adverse effects. Thymoquinone (TQ) has shown potential anti-cancer properties. This systematic review aimed to evaluate the effectiveness of TQ in combination with chemotherapeutic agents in treating breast cancer.</p><p><strong>Methods: </strong>This study thoroughly reviewed and synthesized existing research following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The selected databases, including PubMed, ProQuest, ScienceDirect, Epistemonikos, and Google Scholar, were searched over the past 10 years. Eligibility criteria were based on the PICOS framework, focusing on experimental studies involving TQ-chemotherapy combinations. Data extraction and quality assessment were performed using SYRCLE and SCIRAP tools. This review included 18 <i>in vitro</i> and six <i>in vivo</i> studies.</p><p><strong>Results: </strong>Findings revealed that TQ enhances the efficacy of chemotherapeutic agents by inducing apoptosis, enhancing autophagy, inhibiting tumor growth, and regulating cancer cell signaling pathways as well as multiple phases of the cell cycle. Additionally, TQ reduced chemotherapy-related toxicity, such as heart, blood, liver, and kidney damage, and also improved patient tolerance. Nanoparticle-based delivery systems further amplified these synergistic effects.</p><p><strong>Conclusions: </strong>The TQ-chemotherapy combination shows significant potential as a therapy for breast cancer, enhancing treatment efficacy while mitigating side effects. Future clinical studies are needed to establish its safety and therapeutic applicability.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"17 5","pages":"270-284"},"PeriodicalIF":1.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151103/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical medicine research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/jocmr6230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Breast cancer is a leading malignancy among women globally, with chemotherapy as a cornerstone of treatment. However, the side effects and toxicity associated with chemotherapy necessitate the exploration of adjunctive therapies to improve efficacy and reduce adverse effects. Thymoquinone (TQ) has shown potential anti-cancer properties. This systematic review aimed to evaluate the effectiveness of TQ in combination with chemotherapeutic agents in treating breast cancer.

Methods: This study thoroughly reviewed and synthesized existing research following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The selected databases, including PubMed, ProQuest, ScienceDirect, Epistemonikos, and Google Scholar, were searched over the past 10 years. Eligibility criteria were based on the PICOS framework, focusing on experimental studies involving TQ-chemotherapy combinations. Data extraction and quality assessment were performed using SYRCLE and SCIRAP tools. This review included 18 in vitro and six in vivo studies.

Results: Findings revealed that TQ enhances the efficacy of chemotherapeutic agents by inducing apoptosis, enhancing autophagy, inhibiting tumor growth, and regulating cancer cell signaling pathways as well as multiple phases of the cell cycle. Additionally, TQ reduced chemotherapy-related toxicity, such as heart, blood, liver, and kidney damage, and also improved patient tolerance. Nanoparticle-based delivery systems further amplified these synergistic effects.

Conclusions: The TQ-chemotherapy combination shows significant potential as a therapy for breast cancer, enhancing treatment efficacy while mitigating side effects. Future clinical studies are needed to establish its safety and therapeutic applicability.

百里香醌-化疗联合抗乳腺癌作用:最新体外和体内研究的系统综述。
背景:乳腺癌是全球女性的主要恶性肿瘤,化疗是治疗的基石。然而,化疗的副作用和毒副作用需要探索辅助治疗,以提高疗效,减少不良反应。百里醌(TQ)具有潜在的抗癌作用。本系统综述旨在评价TQ联合化疗药物治疗乳腺癌的有效性。方法:本研究按照系统评价和荟萃分析(PRISMA) 2020指南的首选报告项目,对现有研究进行了全面的回顾和综合。所选数据库包括PubMed、ProQuest、ScienceDirect、Epistemonikos和b谷歌Scholar,检索时间为过去10年。资格标准基于PICOS框架,重点是涉及tq -化疗联合的实验研究。使用sycle和SCIRAP工具进行数据提取和质量评估。本综述包括18项体外研究和6项体内研究。结果:研究发现,TQ通过诱导细胞凋亡、增强细胞自噬、抑制肿瘤生长、调节癌细胞信号通路及细胞周期的多个阶段来增强化疗药物的疗效。此外,TQ减少了化疗相关的毒性,如心脏、血液、肝脏和肾脏的损害,并提高了患者的耐受性。基于纳米颗粒的递送系统进一步放大了这些协同效应。结论:tq -化疗联合治疗乳腺癌具有显著的治疗潜力,可提高治疗效果,减轻副作用。需要进一步的临床研究来确定其安全性和治疗适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.10
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信