Sex-Based Differences in the Association of Epigenetic Age Acceleration with Alzheimer's Disease Biomarkers and Cognitive Measures.

Travyse A Edwards, Tianhua Zhai, Kwangsik Nho, Andrew J Saykin, Qi Long, Li Shen
{"title":"Sex-Based Differences in the Association of Epigenetic Age Acceleration with Alzheimer's Disease Biomarkers and Cognitive Measures.","authors":"Travyse A Edwards, Tianhua Zhai, Kwangsik Nho, Andrew J Saykin, Qi Long, Li Shen","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Alzheimer's Disease (AD) is a neurodegenerative disorder marked by cognitive and functional decline. Biological sex has been linked to differences in lifetime AD risk, AD-related neuropathology, and the rate of cognitive decline, although the underlying biological mechanisms driving these disparities remain unclear. Epigenetic Age Acceleration-a metric derived from epigenetic aging clocks-has been associated with numerous aging-related conditions such as AD. Although there is promise in using Epigenetic age acceleration as a biomarker for several aging related diseases, the underlying mechanism that aging clocks are actually predicting is not well understood. In this study, we used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to examine how sex influences the relationship between age acceleration and cognitive performance as well as brain volume. Our findings suggest that, although epigenetic age acceleration can predict changes in brain structure, these changes don't appear to be different across sexes. Future research should focus on validating these findings in an external cohort and exploring them longitudinally.</p>","PeriodicalId":72181,"journal":{"name":"AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science","volume":"2025 ","pages":"141-148"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150745/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Alzheimer's Disease (AD) is a neurodegenerative disorder marked by cognitive and functional decline. Biological sex has been linked to differences in lifetime AD risk, AD-related neuropathology, and the rate of cognitive decline, although the underlying biological mechanisms driving these disparities remain unclear. Epigenetic Age Acceleration-a metric derived from epigenetic aging clocks-has been associated with numerous aging-related conditions such as AD. Although there is promise in using Epigenetic age acceleration as a biomarker for several aging related diseases, the underlying mechanism that aging clocks are actually predicting is not well understood. In this study, we used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to examine how sex influences the relationship between age acceleration and cognitive performance as well as brain volume. Our findings suggest that, although epigenetic age acceleration can predict changes in brain structure, these changes don't appear to be different across sexes. Future research should focus on validating these findings in an external cohort and exploring them longitudinally.

表观遗传年龄加速与阿尔茨海默病生物标志物和认知测量之间的性别差异
阿尔茨海默病(AD)是一种以认知和功能下降为特征的神经退行性疾病。生物性别与阿尔茨海默病终生风险、阿尔茨海默病相关神经病理和认知能力下降率的差异有关,尽管导致这些差异的潜在生物学机制尚不清楚。表观遗传衰老加速——一种源自表观遗传衰老时钟的指标——与许多与衰老相关的疾病(如阿尔茨海默病)有关。尽管表观遗传衰老加速有望作为几种衰老相关疾病的生物标志物,但衰老时钟实际预测的潜在机制尚未得到很好的理解。在这项研究中,我们使用来自阿尔茨海默病神经影像学倡议(ADNI)的数据来研究性别如何影响年龄加速与认知能力以及脑容量之间的关系。我们的研究结果表明,尽管表观遗传年龄加速可以预测大脑结构的变化,但这些变化似乎在性别之间没有差异。未来的研究应侧重于在外部队列中验证这些发现,并对其进行纵向探索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信