Application of Modified ITBCC Criteria of Tumor Budding in Oral Squamous Cell Carcinoma and its Correlation with Clinicopathological Parameters and Overall Survival.

IF 0.6 Q4 SURGERY

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2025-07-01 Epub Date: 2025-05-20 DOI:10.1007/s12070-025-05575-5

Gaurav Thoke, Deepak Pandiar, Reshma Poothakulath Krishnan

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引用次数: 0

Abstract

Aim: To apply and correlate clinicopathological parameters and survival in oral squamous cell carcinoma (OSCC) with tumor budding using the modified International Tumor Budding Consensus Conference (ITBCC) criteria for colorectal cancer.

Materials and methods: Ethical clearance was sought from the institutional ethical clearance committee, and 121 consecutive cases of excised cases OSCC (with neck dissection and adequate follow-up) were included in the present study. The cases were divided into two groups- with tumor budding (TB) and without TB and were correlated with clinicopathological features. The TB-positive cases were further classified into four classes using modified ITBCC criteria as TB0, TB1, TB2 and TB3. IBM SPSS version 26 was used for analysis, and any value less than or equal to 0.05 was considered statistically significant.

Result: Cases with tumor budding showed more nodal metastasis (p-value: <0.001) and lower overall survival (p-value: 0.038). No significant difference was found between tumor budding and any other clinical and histopathological parameter (p-value: >0.05).

Conclusion: Tumor budding is an independent predictor of nodal metastasis and poorer overall survival in OSCC. Tumor budding at the invasive tumor front should be included in the pathological report and deserves inclusion in staging and grading.

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修订ITBCC肿瘤出芽标准在口腔鳞状细胞癌中的应用及其与临床病理参数和总生存期的相关性。

目的：应用修改后的国际肿瘤出芽共识会议（ITBCC）结直肠癌标准，探讨口腔鳞状细胞癌（OSCC）与肿瘤出芽的临床病理参数和生存率的相关性。材料和方法：获得机构伦理审查委员会的伦理许可，本研究纳入了121例连续切除的OSCC病例（伴有颈部清扫和充分的随访）。这些病例被分为两组——有肿瘤出芽（TB）和没有结核，并与临床病理特征相关。采用修改后的ITBCC标准将结核阳性病例分为TB0、TB1、TB2和TB3 4类。采用IBM SPSS version 26进行分析，小于或等于0.05的值被认为具有统计学意义。结果：肿瘤出芽者有较多淋巴结转移（p值：0.05）。结论：肿瘤出芽是OSCC淋巴结转移和总生存率较差的独立预测因子。侵袭性肿瘤前缘的肿瘤出芽应包括在病理报告中，并应纳入分期和分级。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.80

自引率

0.00%

发文量

226

审稿时长

6-12 weeks

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.