Enhancing working memory in MCI: Modulating alpha-gamma coupling and gamma oscillations via rTMS

IF 6.9 2区医学 Q1 CLINICAL NEUROLOGY

Neurotherapeutics Pub Date : 2025-09-01 DOI:10.1016/j.neurot.2025.e00619

Xiao Yuan , Xiaochen Zhang , Jingnan Sun , Renren Li , Jing Ma , Chenxi Pan , Meng Liu , Hualan Yang , Dan Yang , Fangyun Li , Zhi Bie , Zhen Hu , Yunxia Li

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引用次数: 0

Abstract

Cross-frequency coupling (CFC), particularly the interaction between alpha and gamma oscillations, is a pivotal mechanism implicated in cognitive function, with potential for modulation by repetitive transcranial magnetic stimulation (rTMS). This study aimed to investigate the impact of high-frequency rTMS (HF rTMS) on CFC and visual working memory (VWM) in individuals with mild cognitive impairment (MCI). Twenty MCI patients and twenty healthy controls were administered 10Hz rTMS targeting the left dorsolateral prefrontal cortex (DLPFC). Our critical findings indicate that post-intervention, MCI patients exhibited significant enhancements in VWM performance, notably under low memory load. These improvements correlated with a reduction in occipital gamma activity, and were concurrent with strengthened phase-amplitude coupling (PAC) between frontal alpha and occipital gamma oscillations. The results underscore the capacity of alpha-band HF rTMS to modulate neural activity, offering a promising, non-invasive strategy for enhancing cognitive performance in MCI.

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增强MCI的工作记忆：通过rTMS调制α - γ耦合和γ振荡。

交叉频率耦合（CFC），特别是α和γ振荡之间的相互作用，是涉及认知功能的关键机制，具有通过重复经颅磁刺激（rTMS）调节的潜力。本研究旨在探讨高频rTMS （HF rTMS）对轻度认知障碍（MCI）患者CFC和视觉工作记忆（VWM）的影响。对20例轻度认知障碍患者和20例健康对照进行针对左背外侧前额叶皮质（DLPFC）的10Hz rTMS治疗。我们的关键研究结果表明，干预后，MCI患者的VWM表现显着增强，特别是在低记忆负荷下。这些改善与枕部伽马活动的减少相关，并与额部α和枕部伽马振荡之间的相幅耦合（PAC）增强同时发生。结果强调了α波段高频rTMS调节神经活动的能力，为提高MCI患者的认知表现提供了一种有前途的非侵入性策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotherapeutics 医学-神经科学

CiteScore

11.00

自引率

3.50%

发文量

154

审稿时长

6-12 weeks

期刊介绍： Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities. The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field. Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.