Combining immersive exergaming with physiotherapy in a specialized intensive Parkinson's disease rehabilitation program: a randomized controlled trial.

Abstract

Background: Exergaming is a new technology for implementing innovative rehabilitation interventions for neurological conditions. Our aim was to evaluate the feasibility, safety and efficacy of a novel exergaming experience called neuroanimation, in the form of MindPod^TM Dolphin, added to an intensive physiotherapy program for Parkinson's disease (PD).

Methods: MindPod Dolphin provides a 2D oceanic environment where patients make high-amplitude 3D arm movements controlling an animated dolphin. We conducted a rater-blinded, randomized-controlled trial. Eligible people with PD were assigned into two groups: MindPod Dolphin over 12-weeks combined with physiotherapy (COM) or sequentially after 6-weeks of physiotherapy alone (SEQ). Sessions occurred three times/week. Assessments occurred at baseline, 6-week, 12-week, and 4-week post-intervention. The primary outcome was change from baseline to 6-week in the Timed Up and Go (TUG) test. Secondary outcomes were change, from baseline to each evaluation timepoint, in several motor, cognitive and quality of life measures. Participants' safety was assessed. Adherence, system usability and participants' satisfaction were used as measures of feasibility.

Results: Thirty individuals were recruited. Baseline characteristics were similar between groups. Our primary outcome (change in TUG from baseline to 6-week) did not significantly differ between groups [median TUG change in COM = 0.243 [-1.873, 1.176] vs. SEQ=-0.016 [-0.810, 0.350], estimated difference = 0.002 (95%CI -1.103; 1.273); p = 0.983]. Both groups improved in motor and cognitive measures with a trend favoring COM. When compared to SEQ, COM improved significantly in TUG cognitive from baseline to 16-week (p = 0.048). A main effect of time was observed for TUG cognitive in COM, and mini-BEST in SEQ. Adverse events (n = 309) were mostly mild (55%). Overall, 20 participants (67%) adhered to the study protocol, with the COM being more compliant than the SEQ group. MindPod Dolphin was considered easy to use and over 80% of participants were at least moderately satisfied with it as an intervention.

Conclusions: Neuroanimation-based exergaming in PD was feasible, safe and effective in improving multiple secondary measures. The advantages of the exergame became evident at 12-weeks and beyond, suggesting that it had cumulative and delayed beneficial effects on cognitive and motor outcomes when added to a lead-in phase of intense physiotherapy.

Trial registration: ClinicalTrials.gov registration: NCT04699617.