Nailfold Video Capillaroscopy in Acute and Chronic Skin Graft Versus Host Disease

Mayo Clinic proceedings. Innovations, quality & outcomes Pub Date : 2025-06-13 DOI:10.1016/j.mayocpiqo.2025.100635

Sehreen Mumtaz MBBS , Florentina Berianu MD , Puneet Bhullar MD, MS , Jordan Phillipps MD , Madiha Iqbal MBBS , David Hodge MS , Breanna Cane MPH , Olayemi Sokumbi MD

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引用次数: 0

Abstract

Objective

To assess the utility of nailfold video capillaroscopy (NVC) in patients diagnosed with acute and chronic graft versus host disease (GVHD) of the skin.

Patients and Methods

Patients diagnosed with acute and chronic skin GVHD (n=11) and those without the diagnosis of GVHD (controls) (n=21) underwent NVC to assess capillary density, morphology, and hemorrhage. Statistical comparisons were made using Fisher’s exact test. The study was performed from March 1, 2024, to August 1, 2024.

Results

Patients diagnosed with acute and chronic GVHD were observed to have considerably more microhemorrhages, ramifications, and disorganized capillaries when compared with patients without a diagnosis of acute or chronic GVHD.

Conclusion

This study reveals significant NVC abnormalities in patients with GVHD, suggesting distinct microvascular features that imply potential diagnostic value. The NVC may be a valuable tool for diagnosing and monitoring GVHD and warrants further investigation in larger cohorts.

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甲襞视频毛细血管镜在急慢性皮肤移植物抗宿主病中的应用

目的评价甲襞视频毛细血管镜（NVC）在急性和慢性皮肤移植物抗宿主病（GVHD）患者中的应用价值。患者和方法诊断为急性和慢性皮肤GVHD的患者（n=11）和未诊断为GVHD的患者（n=21）采用NVC评估毛细血管密度、形态和出血。采用Fisher精确检验进行统计比较。研究时间为2024年3月1日至2024年8月1日。结果与未诊断为急性或慢性GVHD的患者相比，诊断为急性和慢性GVHD的患者观察到明显更多的微出血，分支和毛细血管紊乱。结论本研究显示GVHD患者有明显的NVC异常，提示不同的微血管特征，具有潜在的诊断价值。NVC可能是诊断和监测GVHD的一种有价值的工具，值得在更大的队列中进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mayo Clinic proceedings. Innovations, quality & outcomes Surgery, Critical Care and Intensive Care Medicine, Public Health and Health Policy

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审稿时长

49 days