Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report

Pediatric Hematology Oncology Journal Pub Date : 2025-06-01 DOI:10.1016/j.phoj.2025.100457

A. Roggero , L. Piro , D. Paoloni , F. Palo , S. Avanzini , V. Capra , P. De Marco , S. Sorrentino , E. Arkhangelskaya , J. Ferro , V.G. Vellone , M. Conte

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Abstract

Background

Multiple malignant neoplasms in pediatric patients are rare, posing diagnostic and therapeutic challenges. This case report details a 12-year-old girl with a Yolk Sac Tumor (YST) found to have a Solid Pseudopapillary Neoplasm (SPN) of the pancreas, highlighting management complexities.

Case report

A 12-year-old girl presented with pelvic pain and dysuria. Imaging revealed a right ovarian mass, confirmed as YST. A partial ovariectomy was performed. Persistent abdominal pain led to further investigation, revealing a pancreatic lesion and residual ovarian mass. Multidisciplinary management included salpingo-oophorectomy and distal pancreatectomy, achieving complete tumor resection. Genetic testing, including Whole Exome Sequencing of 400 cancer predisposition genes, found no significant variants.

Conclusion

The synchronous occurrence of YST and SPN in pediatric patients, without pathogenic variants, is extremely rare. Management involved surgery, chemotherapy for YST, and individualized SPN treatment. Long-term follow-up is essential due to the malignancy potential of both tumors.

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小儿卵巢卵黄囊肿瘤合并胰腺实性假乳头状肿瘤1例报告

背景：小儿多发恶性肿瘤非常罕见，这给诊断和治疗带来了挑战。本病例报告详细描述了一名12岁女孩的卵黄囊肿瘤（YST），发现胰腺有实性假乳头状肿瘤（SPN），突出了治疗的复杂性。病例报告：一名12岁女孩以盆腔疼痛和排尿困难表现。影像显示右侧卵巢肿块，确认为YST。行部分卵巢切除术。持续腹痛导致进一步检查，发现胰腺病变和卵巢残余肿块。多学科治疗包括输卵管卵巢切除术和远端胰腺切除术，实现肿瘤完全切除。基因测试，包括400个癌症易感性基因的全外显子组测序，没有发现显著的变异。结论小儿YST和SPN同时发生，无致病变异，极为罕见。治疗包括手术、YST化疗和个体化SPN治疗。由于两种肿瘤的恶性潜能，长期随访是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Hematology Oncology Journal

CiteScore

1.00

自引率

0.00%

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