MBaFus: A Virtual Lab of Microbubble-Augmented Focused Ultrasound for Noninvasive Tumor Ablation Based on Two-Way Coupled Euler-Lagrange Modeling.

IF 0.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Jingsen Ma, Chao-Tsung Hsiao, Aswin Gnanaskandan, Xiaolong Deng
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引用次数: 0

Abstract

Focused ultrasound (FUS), especially when augmented by microbubbles (MBs), shows the potential for noninvasive ablation of deep-seated tumors, but its clinical adoption is hindered due to its dependency on multiple controllable parameters of FUS and MBs. To accelerate the clinical transition of this noninvasive and target therapy, a virtual lab featuring a two-way coupled Euler-Lagrange computation platform, capable of capturing physics down to individual MBs thus their nonlinear interactions, has been developed to accurately predict the acoustic and thermal fields for microbubble-augmented FUS (MBaFus), and subsequently the resultant temperature rise at the treatment spots. This technical brief concisely summarizes the main features of its numerical algorithms for prediction and high-performance computing schemes for speedup, as well as its preliminary validation against in vitro experiments. Recent progress on further evaluating the numerical virtual lab under ex vivo settings is reported, where FUS treatment for ex vivo porcine liver was conducted and MB augmentation effects to treatment outcome under different MB conditions were compared. It is found that the agreement between our numerical prediction and experimental measurements in the referred ex vivo study is reasonably satisfactory. Though more extensive validations are needed when extra ex vivo studies in the public domain become available, this intermediate progress illustrates the potential of this novel numerical platform serving as a virtual lab of microbubble-augmented FUS for noninvasive tumor ablation.

基于双向耦合欧拉-拉格朗日模型的微泡增强聚焦超声无创肿瘤消融虚拟实验室。
聚焦超声(Focused ultrasound, FUS),尤其是经微泡(micro泡)增强后,显示出对深部肿瘤无创消融的潜力,但由于其依赖于FUS和MBs的多个可控参数,阻碍了其临床应用。为了加速这种非侵入性和靶向治疗的临床过渡,已经开发了一个具有双向耦合欧拉-拉格朗日计算平台的虚拟实验室,能够捕获单个mb的物理特性,从而实现它们的非线性相互作用,以准确预测微泡增强FUS (MBaFus)的声场和热场,以及随后在治疗点产生的温升。本技术简介简要总结了其用于预测的数值算法和用于加速的高性能计算方案的主要特点,以及其在体外实验中的初步验证。本文报道了在离体条件下进一步评估数字虚拟实验室的最新进展,其中对离体猪肝进行了FUS治疗,并比较了不同MB条件下MB增强对治疗结果的影响。在离体研究中,我们的数值预测和实验测量结果之间的一致性是相当令人满意的。虽然需要在公共领域进行更多的离体研究时进行更广泛的验证,但这一中间进展说明了这种新型数值平台作为微泡增强FUS用于非侵入性肿瘤消融的虚拟实验室的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.80
自引率
11.10%
发文量
56
审稿时长
6-12 weeks
期刊介绍: The Journal of Medical Devices presents papers on medical devices that improve diagnostic, interventional and therapeutic treatments focusing on applied research and the development of new medical devices or instrumentation. It provides special coverage of novel devices that allow new surgical strategies, new methods of drug delivery, or possible reductions in the complexity, cost, or adverse results of health care. The Design Innovation category features papers focusing on novel devices, including papers with limited clinical or engineering results. The Medical Device News section provides coverage of advances, trends, and events.
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