Bixian Luo, Zelai Wu, Chengyu Hu, Weixun Xie, Jun He, Hongming Liu, Dong Cao, Yong Liu, Yuxin Zhong, Weihua Gong
{"title":"Alpha fetoprotein (AFP)-producing gastric cancer: clinicopathological features and treatment strategies.","authors":"Bixian Luo, Zelai Wu, Chengyu Hu, Weixun Xie, Jun He, Hongming Liu, Dong Cao, Yong Liu, Yuxin Zhong, Weihua Gong","doi":"10.1186/s13578-025-01424-8","DOIUrl":null,"url":null,"abstract":"<p><p>Alpha-fetoprotein (AFP) is a widely recognized tumor marker for hepatocellular carcinoma and yolk sac tumors. Alpha-fetoprotein-producing gastric cancer (AFPGC) is a rare but highly malignant subtype of gastric cancer associated with poor prognosis. It is characterized by AFP positivity detected in serum or immunohistochemical staining, may along with hepatocellular differentiation. In recent years, advancements in molecular biology and therapeutic agents have led to a deeper understanding of AFPGC. However, the mechanisms underlying its tumorigenesis and invasive metastasis remain unclear. This article summarizes the traits of AFP, its clinicopathological features, and therapeutic strategies for AFP-positive gastric cancer, providing a better understanding and reference for the clinical diagnosis and treatment of AFPGC.</p>","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":"15 1","pages":"82"},"PeriodicalIF":6.1000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153134/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Bioscience","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s13578-025-01424-8","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Alpha-fetoprotein (AFP) is a widely recognized tumor marker for hepatocellular carcinoma and yolk sac tumors. Alpha-fetoprotein-producing gastric cancer (AFPGC) is a rare but highly malignant subtype of gastric cancer associated with poor prognosis. It is characterized by AFP positivity detected in serum or immunohistochemical staining, may along with hepatocellular differentiation. In recent years, advancements in molecular biology and therapeutic agents have led to a deeper understanding of AFPGC. However, the mechanisms underlying its tumorigenesis and invasive metastasis remain unclear. This article summarizes the traits of AFP, its clinicopathological features, and therapeutic strategies for AFP-positive gastric cancer, providing a better understanding and reference for the clinical diagnosis and treatment of AFPGC.
期刊介绍：
Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.
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