Cuproptosis and cuproptosis-related cell death and genes: mechanistic links to spermatogenic cell death.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-06-10 DOI:10.1038/s41420-025-02553-2

Junjun Li, Nihong Li, Hong Wang, Bin Li, Xinyi Tang, Yanxin Guan, Fang Yang, Guangsen Li, Liang Dong, Renbin Yuan, Xujun Yu

引用次数: 0

Abstract

Spermatogenesis, which is regulated by multiple cell death mechanisms, is an extremely complex process. The significance of cell death during spermatogenesis is a topic of interest because of its potential medical implications. Cuproptosis is a new mechanism of cell death discovered in recent years, and recent studies have preliminarily confirmed that cuproptosis is involved in the process of spermatogenic cell death, but its specific role in the process of spermatogenic cell death is still unclear. In this review, the mechanisms of spermatogenic cell death associated with cuproptosis and the effects of key genes of cuproptosis on spermatogenesis are discussed together with some new perspectives for the study of spermatogenic cell death.

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铜裂和铜裂相关的细胞死亡和基因：与生精细胞死亡的机制联系。

精子发生是一个极其复杂的过程，受多种细胞死亡机制的调控。精子发生过程中细胞死亡的意义是一个令人感兴趣的话题，因为它具有潜在的医学意义。cuprotosis是近年来发现的一种新的细胞死亡机制，近年来的研究初步证实cuprotosis参与了生精细胞死亡的过程，但其在生精细胞死亡过程中的具体作用尚不清楚。本文从生精细胞死亡的机制、生精关键基因对精子发生的影响等方面进行了综述，并对生精细胞死亡研究的新方向进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.