What's New in Wound Healing: Treatment Advances and Microbial Insights.

IF 8.6 1区医学 Q1 DERMATOLOGY

American Journal of Clinical Dermatology Pub Date : 2025-06-11 DOI:10.1007/s40257-025-00953-9

Gabriela E Beraja, Fiona Gruzmark, Irena Pastar, Hadar Lev-Tov

{"title":"What's New in Wound Healing: Treatment Advances and Microbial Insights.","authors":"Gabriela E Beraja, Fiona Gruzmark, Irena Pastar, Hadar Lev-Tov","doi":"10.1007/s40257-025-00953-9","DOIUrl":null,"url":null,"abstract":"<p><p>Recent advancements in wound healing are reshaping clinical practice by integrating dermatology, cutaneous microbiome research, and technology. This article discusses new diagnostic tools, such as imaging devices and microbial composition analysis, that enhance our understanding of wound environments. It highlights the importance of wound bed preparation and explores innovative treatment methods for optimal wound healing, including debridement techniques like ultrasound-assisted methods, hydrosurgery, and larval therapy. The evolution of wound management is further illustrated through the use of cellular and acellular matrix products and cellular therapies involving whole blood products. We also present the latest insights on the wound microbiome and antimicrobial treatments, including advanced dressings and antibiofilm surfactants. Finally, the potential of gene therapy for complex conditions like epidermolysis bullosa is discussed as a promising model for advancing wound healing. This review synthesizes current research to improve dermatological practices and patient outcomes in wound care.</p>","PeriodicalId":7706,"journal":{"name":"American Journal of Clinical Dermatology","volume":" ","pages":""},"PeriodicalIF":8.6000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Clinical Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40257-025-00953-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Recent advancements in wound healing are reshaping clinical practice by integrating dermatology, cutaneous microbiome research, and technology. This article discusses new diagnostic tools, such as imaging devices and microbial composition analysis, that enhance our understanding of wound environments. It highlights the importance of wound bed preparation and explores innovative treatment methods for optimal wound healing, including debridement techniques like ultrasound-assisted methods, hydrosurgery, and larval therapy. The evolution of wound management is further illustrated through the use of cellular and acellular matrix products and cellular therapies involving whole blood products. We also present the latest insights on the wound microbiome and antimicrobial treatments, including advanced dressings and antibiofilm surfactants. Finally, the potential of gene therapy for complex conditions like epidermolysis bullosa is discussed as a promising model for advancing wound healing. This review synthesizes current research to improve dermatological practices and patient outcomes in wound care.

查看原文本刊更多论文

伤口愈合的新进展：治疗进展和微生物的见解。

伤口愈合的最新进展正在通过整合皮肤病学、皮肤微生物组研究和技术来重塑临床实践。本文讨论了新的诊断工具，如成像设备和微生物组成分析，提高了我们对伤口环境的理解。它强调了伤口床准备的重要性，并探索了最佳伤口愈合的创新治疗方法，包括超声辅助方法，水手术和幼虫治疗等清创技术。伤口管理的演变通过使用细胞和非细胞基质产品以及涉及全血制品的细胞疗法进一步说明。我们还介绍了伤口微生物组和抗菌治疗的最新见解，包括先进的敷料和抗生物膜表面活性剂。最后，讨论了基因治疗复杂疾病的潜力，如大疱性表皮松解症，作为促进伤口愈合的有前途的模式。这篇综述综合了目前的研究，以改善皮肤病学实践和伤口护理患者的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American Journal of Clinical Dermatology 医学-皮肤病学

CiteScore

15.20

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.